DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 301 - 310 of 319

Investigator:Katrina Paumier


Title:Antidepressant-mediated disease-modifying effects in ADAD

Date of Request:7/5/2016

ID:DIAN-D1614




Aim 1:Determine whether antidepressant treatment reduces brain amyloid deposition (PET)




Aim 2:Determine if antidepressants alter CSF biomarkers (A-beta, tau, ptau, etc.)




Aim 3:Determine if the onset of symptoms is delayed in antidepressant treated individuals.




Aim 4Assess whether the rate of disease progression is slowed with antidepressant treatment (DPM)

Investigator:M Ewers


Title:Association between CSF sTREM2 and white matter changes

Date of Request:8/5/2016

ID:DIAN-D1616




Aim 1:Test whether higher CSF sTREM2 is associated with stronger WMH volume, fiber tract damage (DTI) and lower functional connetivity










Investigator:Michael Ewers


Title:Is global connectivity of the left frontal cortex a neural substrate of reserve in subjects with autosomal dominant Alzheimer's disease?

Date of Request:8/7/2016

ID:DIAN-D1615




Aim 1:To test whether LFC connectivity is associated with protective factors such as years of education, IQ, leisure activities (i.e. years of education, IQ)




Aim 2:To test whether LFC connectivity is associated with higher cognitive performance at any given level of disease severity




Aim 3:To test whether LFC changes with disease severity during the course of AD and relates to dementia symptom onset




Investigator:Jason Hassenstab


Title:Developing the DIAN-TU Cognitive Endpoint

Date of Request:8/17/2016

ID:DIAN-D1617




Aim 1:Evaluate combinations of cognitive tests in order to develop the most sensitive composite score for use as the primary cognitive endpoint in the DIAN-TU trial.










Investigator:Jason Hassenstab


Title:Evaluating the utility of �run-in� data for use in AD prevention trials: Results from the DIAN observational study

Date of Request:8/17/2016

ID:DIAN-D1618




Aim 1:To evaluate the utility of including �run-in� data to increase power to detect a treatment effect.










Investigator:Serge Gauthier


Title:Neuropsychiatric Symptoms Predicting Neurodegeneration In Asymptomatic Autosomal Dominant Alzheimer?s Disease Mutation Carriers

Date of Request:8/25/2016

ID:DIAN-D1619




Aim 1:Test the hypothesis that the magnitude of neuropsychiatric symptoms predicts subsequent cingulate hypometabolism in asymptomatic ADAD mutation carriers over 24 months.




Aim 2:Replicate our findings obtained from the ADNI cohort in which baseline Neuropsychiatric Inventory (NPI) predicts neurodegeneration in cognitively normal individuals with preclinical AD.







Investigator:JC Morris


Title:APOE4 effect on brains tructure and function in cognitively normal young-to-middle age adults

Date of Request:8/26/2016

ID:DIAN-D1620




Aim 1:DIAN NCs with an E4 allele will have greater risk of having an "Alzheimer signature"










Investigator:Timothy Hohman


Title:Building a Resilience Phenotype in DIAN

Date of Request:9/1/2016

ID:DIAN-D1621




Aim 1:Define a resilience phenotype in the cohort based on better-than-expected cognition and hippocampal volume given an individuals level of AD biomarkers










Investigator:Hungbo Luo


Title:Tauopathy in Autosomal Dominant and Late-Onset Alzheimer Disease

Date of Request:9/27/2016

ID:DIAN-D1622




Aim 1:Determine the relative burden of tauopathy in archicortical and neocortical areas in ADAD and LOAD using unbiased stereologic methods.




Aim 2:Determine the contribution of different lesions (neuropil threads, dystrophic neurites, and neurofibrillary tangles) to the overall tau burden in neocortical and archicortical regions.




Aim 3:Determine the relationship between the clinical phenotypes of LOAD and ADAD and spatial patterns of tauopathy.




Investigator:NA


Title:Attentional Control in Dominantly Inherited Alzheimer disease

Date of Request:9/28/2016

ID:DIAN-D1623




Aim 1:Establish rates of change in attentional control in DIAN




Aim 2:Evaluate alternative measures of performance using compuational modelling







Displaying 301 - 310 of 319