DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 281 - 290 of 319

Investigator:Ryoko Ihara

Title:Outcomes from awareness of mutation status in DIAN study

Date of Request:8/21/2015

ID:DIAN-D1512

Aim 1:To investigate how awareness of mutation status affects mental status and cognitive decline both in short term and long term

Aim 2:To investigate how awareness of mutation status before participation affects motivation for the study participation afterwards

Investigator:Serge Gauthier

Title:Neurobiological Markers of Suicide Vulnerability in Alzheimer?s Disease Patients

Date of Request:9/3/2015

ID:DIAN-D1513

Aim 1:to characterize neurobiological markers (socio-demographic, clinical, neuropsychological, and biological profile) of asymptomatic ADAD mutation carriers and symptomatic ADAD mutation carriers with suicidal ideations (suicidal patients).

Aim 2:to compare neurobiological markers (socio-demographic, clinical, neuropsychological, and biological) in a) asymptomatic ADAD mutation carriers suicidal patients, b) symptomatic ADAD mutation carriers suicidal patients, c) asymptomatic non-mutation carrier non-suicidal controls, and to d) symptomatic

Investigator:NA

Title:Examining the relationship between exercise, Aβ accumulation, brain atrophy and age at onset: A study of autosomal-dominant Alzheimer?s disease mutation carriers

Date of Request:11/3/2015

ID:DIAN-D1514

Aim 1:1. Examine the rates of brain Aβ accumulation between exercising and sedentary asymptomatic mutation carriers, versus aged matched non-mutation carriers.

Aim 2:2. Examine rates of hippocampal and prefrontal cortex atrophy between exercising and sedentary asymptomatic mutation carriers, versus aged matched non-mutation carriers.

Aim 3:3. Examine the relationship between baseline exercise levels and age at onset in symptomatic mutation carriers.

Investigator:John Ringman/JJ Wang

Title:Microhemorrhages and vascular compliance

Date of Request:11/9/2015

ID:DIAN-D1515

Aim 1:To relate number of micro hemorrhages to cerebrovascular compliance for UCLA DIAN subjects

Investigator:Prof. Dr. Adrian Danek

Title:Frequency of seizures in the DIAN cohort: A comparison between mutation carriers and non-carriers

Date of Request:11/23/2015

ID:DIAN-D1516

Aim 1:Our specific aim for our proposed work with the DIAN data set is to find out whether there is a difference in frequency of seizures in mutation carriers of familial Alzheimer?s disease in comparison to non-carriers.

Aim 2:Furthermore we are planning to follow an enhanced approach by querying the NACC data base for a comparison of frequency of seizures between patients with sporadic Alzheimer?s disease, mutation carriers for the familial Alzheimer?s disease and non-carriers.

Aim 3:A further possibility is to additionally include patients with frontotemporal lobar degeneration for comparison of frequency of seizures.

Investigator:Randall J Bateman

Title:DIAN-TU NexGen Trial Design Manuscript

Date of Request:12/29/2015

ID:DIAN-D1517

Aim 1:Disseminate DIAN-TU NexGen trial design analyses

Aim 2:Optimize DIAN-TU cognitive composite for the primary endpoint

Aim 3:Develop a desease progression model for autosomal dominant Alzheimer's disease

Aim 4Evaluate the benefits of run-in data to enhance trial statistical power and identify a drug effect

Investigator:Karch

Title:Clinical and Molecular Characterization of Novel PSEN1 Mutation

Date of Request:1/8/2016

Status:Pending

ID:DIAN-D1601

Aim 1:To describe the biomarker (fluid and imaging) profile for research participants from a family with a novel PSEN1 mutation

Investigator:NA

Title:State space modeling of the clinical and biomarker changes in Dominantly Inherited Alzheimer?s Disease

Date of Request:1/15/2016

ID:DIAN-D1602

Aim 1:Apply state space model to DIAN data to estimate the clinical and biomarker changes in Dominantly Inherited Alzheimer's Disease

Aim 2:Compare the results from state space model with the result from the mixed model

Aim 3:Simulate Alzheimer's disease clinical trials based on the DIAN data and to propose statistical test methods for efficacy

Investigator:Dawn Matthews

Title:Multimodality Imaging Diagnostic for Preclinical and Prodromal AD

Date of Request:1/25/2016

ID:DIAN-D1603

Aim 1:Further refine and validate our use of early frame amyloid data as a marker of disease and predictor of functional change

Aim 2:Refine and validate PET and structural MRI classifiers in differentiating amyloid positive and negative populations and predicting rate of clinical decline.

Aim 3:Optimize processing and classification approaches to functional MRI data as available to characterize disease state and progression

Aim 4Compare imaging markers of disease progression in the DIAN population to Late Onset populations

Investigator:Eric McDade

Title:Task Based Functional MRI in Preclinical Autosomal Dominant Alzheimer Dementia

Date of Request:1/27/2016

ID:DIAN-D1604

Aim 1:To identify differences in neuronal network function during working memory and learning in preclinical ADAD

Aim 2:To explore the association of task-based functional MRI activity in preclinical mutation carriers with imaging and CSF based AD pathology.

Aim 3:To explore task-based function MRI activity with longitudinal PET amyloid deposition.