Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 131 - 140 of 318

Investigator:Colin L Masters


Title:Alzheimer's dementia onset and progression in international cohorts

Date of Request:09/23/2019




Aim 1:Using unsupervised machine learning techniques (latent Gaussian processes, auto encoders, disentanglement) in order to identify ‘pure’ (and potentially highly non-linear) Alzheimer factors using DIAN cohort.




Aim 2:Study the utility of the resulting latent structure for progression prediction of the late-onset patients.







Investigator:LD Sibley


Title:Role of toxoplasmosis in AD

Date of Request:09/09/2019




Aim 1:Evaluate differences in amyloid PET based on Toxoplasma serological status




Aim 2:Evaluate differences in cognative function based on Toxoplasma serological status







Investigator:Belinda Brown


Title:The effect of exercise participation on Aβ accumulation, CSF biomarkers and brain atrophy and age at onset

Date of Request:08/27/2019




Aim 1:1. Compare the rates of brain Aβ accumulation between exercising and sedentary asymptomatic mutation carriers.




Aim 2:2. Compare longitudinal changes in CSF levels of Aβ and tau between exercising and sedentary asymptomatic mutation carriers.




Aim 3:3. Compare rates of hippocampal and prefrontal cortex atrophy between exercising and sedentary asymptomatic mutation carriers.




Aim 44. Examine the relationship between baseline exercise levels and age at onset in symptomatic mutation carriers.

Investigator:Anne Fagan


Title:Head to head comparison of CSF assay platforms for identifying amyloid positivity

Date of Request:08/20/2019




Aim 1:To compare the analytic performance of the two automated assay platforms (Elecsys and Lumipulse) for measurement of CSF AB40, AB42, total tau and ptau181 in a common sub-cohort of DIAN samples




Aim 2:To define the best-performing CSF biomarker cut-point(s) for amyloid PET positivity for each of the assay platforms







Investigator:Martha Brumfield


Title:Drug-disease-trial model for Alzheimer's prevention drug development

Date of Request:07/22/2019




Aim 1:Develop a drug-disease trial model to optimize clinical trial design in Alzheimer's prevention




Aim 2:Submit the model for regulatory endorsement at FDA and EMA




Aim 3:Develop a graphical user interface for the model




Aim 4Make model publicly available

Investigator:Andrew Yoo


Title:Modelling Alzheimer’s disease with human neurons generated by direct conversion (reprogramming) of patient fibroblasts

Date of Request:07/14/2019




Aim 1:Developing cellular models of AD through direct neuronal reprogramming




Aim 2:Application of direct neuronal reprogramming in patient fibroblasts







Investigator:Helena Chui


Title:Biomarker Characterization of a Novel Truncation Mutation in PSEN1

Date of Request:07/13/2019

Status:approved

ID:DIAN-D1920




Aim 1:To describe CSF profile of AD biomarkers including but not limited to Abeta and tau subspecies in a patient with a novel truncation mutation in PSEN1




Aim 2:To describe imaging characteristics (MRI, FDG, Amyloid PET) of the novel PSEN1 truncation mutation







Investigator:Guoqiao Wang


Title:Select Eligible DIAN-OBS Participants for the DIAN-TU Primary Analysis

Date of Request:07/10/2019




Aim 1:Select Eligible DIAN-OBS Participants for the DIAN-TU Primary Analysis










Investigator:Nick Fox


Title:Psychosis in dominantly inherited Alzheimer’s disease

Date of Request:07/08/2019




Aim 1:To determine the frequency of psychosis in DIAN family members, and to explore associations between psychosis and different genotypes




Aim 2:To examine the relationship between neuropsychiatric symptoms and estimated years to and from cognitive symptom onse




Aim 3:3. To determine if there is a relationship, and any potential interaction, between psychotic symptoms and previously reported risk/modifier alleles (5HT2A receptor polymorphism, SNPs in RP11-541P9.3, ApoE status) and environmental risk factors (e.g. history of substance abuse)




Aim 44. To explore associations between neuropsychiatric symptoms and fluid, imaging and cognitive biomarkers of disease

Investigator:Nick Fox


Title:Longitudinal tau PET in dominantly inherited Alzheimer’s disease

Date of Request:07/04/2019




Aim 1:a) to understand the role tau PET imaging can play as a marker of early Alzheimer’s disease for clinical diagnostic purposes and also as a biomarker in trials of individuals with autosomal dominantly inherited forms of Alzheimer’s disease (ADAD)




Aim 2:b) to optimize static and dynamic methods of tau PET analysis in order to achieve better longitudinal consistency and reduce sources of within-subject variability




Aim 3:c) to improve understanding of when and where tau deposition occurs, and how these relationships change over time;




Aim 4d) to determine the relationship between changes in tau deposition and changes related to neurodegeneration and cognitive decline; and

Displaying 131 - 140 of 318