Search DIAN Data Resource Requests

In order to avoid the situation where two investigators study the same research question, please search our database to determine if your topic has already been studied. If you find that your topic or a related topic has already been submitted, you may wish to contact the investigator to inquire about his/her findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID # (e.g. DIAN-D1004), the full request has been submitted and is either approved, disapproved or in process.

Displaying 221 - 230 of 294

Investigator:Anne Fagan


Title:Relationship between CSF cell counts and biomarkers

Date of Request:7/18/2013

Status:A

ID:DIAN-D1309




Aim 1:To assess the relationship between CSF cell counts and biomarker levels










Investigator:Tammie Benzinger


Title:Analysis of cortical volume as a risk factor for post lumbar puncture headache

Date of Request:7/24/2013

Status:A

ID:DIAN-D1310




Aim 1:To determine whether cortical volume is a risk factor for post lumbar puncture headache










Investigator:Jurgen Claassen


Title:Association between amyloid-beta, systemic (blood pressure) and brain vascular changes.

Date of Request:9/24/2013

Status:A

ID:DIAN-D1311




Aim 1:To investigate associations between amyloid-β accumulation (carrier vs non-carrier) and baseline blood pressure changes




Aim 2:To investigate associations between amyloid-β accumulation (carrier vs non-carrier) and visit to visit blood pressure variability




Aim 3:To investigate associations between amyloid-β accumulation (carrier vs non-carrier) and cerebral blood flow (derived from PET)




Investigator:Jeffrey Petrella


Title:The Alzheimer's Connectome: Relationships between structural and functional changes in the DIAN population

Date of Request:10/9/2013

Status:A

ID:DIAN-D1312




Aim 1:Determine whether changes in the structural connectome are associated with changes in the functional connectome across diagnostic groups in the DIAN population




Aim 2:Determine whether changes in the structural connectome are affected by increasing beta amyloid burden in the DIAN population.







Investigator:Juergen Dukart


Title:Linking connectivity and structural patterns in AD

Date of Request:10/11/2013

Status:IP

ID:DIAN-D1313




Aim 1:Establishing a resting state connectivity pattern in AD




Aim 2:Linking structural and resting state connectivity biomarkers







Investigator:Mathias Jucker


Title:Sample sizes for different EYO intervals with and without amyloid

Date of Request:11/1/2013

Status:IP

ID:DIAN-D1314




Aim 1:Determine sample sizes for different EYO intervals with and without amyloid










Investigator:Nick Fox


Title:Rates of longitudinal microstructural change in familial AD using diffusion weighted imaging

Date of Request:11/11/2013

Status:IP

ID:DIAN-D1315




Aim 1:Estimate rates of change in microstructure diffusion measurements (FA, MD, radial and axial diffusivity) in familial Alzheimer’s disease




Aim 2:Determine at what point in time do these changes diverge from non-carriers




Aim 3:Calculate sample sizes needed to detect a substantial treatment effect within a clinical trial similar to the population that will enter the DIAN clinical trials




Investigator:David Teplow


Title:Imaging and biomarker correlates of spastic paraparesis associated with PSEN1 mutations

Date of Request:11/21/2013

Status:IP

ID:DIAN-D1316




Aim 1:To compare white matter, among persons with PSEN1 mutations, between those with and without spastic paraparesis using DTI




Aim 2:To compare cerebral amyloidosis, among persons with PSEN1 mutations, between those with and without spastic paraparesis using PIB images







Investigator:Prof. Ralph Martins


Title:Plasma and cerebrospinal fluid phospholipid profiles in a DIAN cohort subset

Date of Request:11/22/2013

Status:A

ID:DIAN-D1317




Aim 1:To find phospholipid species which significantly differ in concentrations between mutation carriers and non carriers.




Aim 2:To correlate the phospholipid species obtained in aim 1, with the established gold standard biomarkers such as PiB-PET SUVR, cerebrospinal fluid concentrations of total-tau, phosphorylated-tau and Aβ42.




Aim 3:correlate the plasma phospholipid species obtained in aim 1, with FDG-PET SUVR, MRI data and plasma Abeta levels.




Investigator:Arthur Toga


Title:Alzheimer's Disease Biomarkers via a Multimodal statistical approach

Date of Request:12/11/2013

Status:IP

ID:DIAN-D1318




Aim 1:Determine imaging and clinical biomarkers for the risk of Alzheimer's Diease




Aim 2:Conceputalize a target sample size that could be used for clinical trials based on the power of targeted biomarkers







Displaying 221 - 230 of 294