DIAN Observational Study Publications

    1. Farzaneh Rahmani, Matthew R. Brier, Brian A. Gordon, Nicole McKay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph‐Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A. Raji, Jorge J. Libre‐Guerra, Richard J. Perrin, Eric McDade, Alisha Daniels, Celeste Karch, Gregory S. Day, Adam M. Brickman, Michael Fulham, Clifford R. Jack, Jr, Christian la La Fougère, Gerald Reischl, Peter R. Schofield, Hwamee Oh, Johannes Levin, Jonathan Vöglein, David M. Cash, Igor Yakushev, Takeshi Ikeuchi, William E. Klunk, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, For the Dominantly Inherited Alzheimer Network (DIAN). T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease. Hum Brain Mapp. 2023 Dec 15; 44(18): 6375–6387. Published online 2023 Oct 23. doi: 10.1002/hbm.26514 PMCID: PMC10681640
    2. Jiaxin Cindy Tu, Peter R. Millar, Jeremy F. Strain, Andrew Eck, Babatunde Adeyemo, Alisha Daniels, Celeste Karch, Edward D. Huey, Eric McDade, Gregory S. Day, Igor Yakushev, Jason Hassenstab, John Morris, Jorge J. Llibre-Guerra, Laura Ibanez, Mathias Jucker, Patricio Chrem Mendez, Randell J. Bateman, Richard J. Perrin, Tammie Benzinger, Clifford R. Jack, Jr, Richard Betzel, Beau M. Ances, Adam T. Eggebrecht, Brian A. Gordon, Muriah D. Wheelock, Dominantly Inherited Alzheimer Network. Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease Version 1. bioRxiv. Preprint. 2023 Nov 1. doi: 10.1101/2023.10.29.564633 PMCID: PMC10634945
    3. Jorge J Llibre-Guerra, Leonardo Iaccarino, Dean Coble, Lauren Edwards, Yan Li, Eric McDade, Amelia Strom, Brian Gordon, Nidhi Mundada, Suzanne E Schindler, Elena Tsoy, Yinjiao Ma, Ruijin Lu, Anne M Fagan, Tammie L S Benzinger, David Soleimani-Meigooni, Andrew J Aschenbrenner, Zachary Miller, Guoqiao Wang, Joel H Kramer, Jason Hassenstab, Howard J Rosen, John C Morris, Bruce L Miller, Chengjie Xiong, Richard J Perrin, Ricardo Allegri, Patricio Chrem, Ezequiel Surace, Sarah B Berman, Jasmeer Chhatwal, Colin L Masters, Martin R Farlow, Mathias Jucker, Johannes Levin, Nick C Fox, Gregory Day, Maria Luisa Gorno-Tempini, Adam L Boxer, Renaud La Joie, Gil D Rabinovici, Randall Bateman. Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer’s disease. Brain Commun. 2023; 5(6): fcad280. Published online 2023 Oct 18. doi: 10.1093/braincomms/fcad280 PMCID: PMC10629466
    4. Johnson ECB, Bian S, Haque RU, Carter EK, Watson CM, Gordon BA, Ping L, Duong DM, Epstein MP, McDade E, Barthélemy NR, Karch CM, Xiong C, Cruchaga C, Perrin RJ, Wingo AP, Wingo TS, Chhatwal JP, Day GS, Noble JM, Berman SB, Martins R, Graff-Radford NR, Schofield PR, Ikeuchi T, Mori H, Levin J, Farlow M, Lah JJ, Haass C, Jucker M, Morris JC, Benzinger TLS, Roberts BR, Bateman RJ, Fagan AM, Seyfried NT, Levey AI; Dominantly Inherited Alzheimer Network. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease. Nat Med. 2023 Aug;29(8):1979-1988. doi: 10.1038/s41591-023- 02476-4. Epub 2023 Aug 7. PMID: 37550416; PMCID: PMC10427428.
    5.  McKay NS, Gordon BA, Hornbeck RC, Dincer A, Flores S, Keefe SJ, Joseph-Mathurin N, Jack CR, Koeppe R, Millar PR, Ances BM, Chen CD, Daniels A, Hobbs DA, Jackson K, Koudelis D, Massoumzadeh P, McCullough A, Nickels ML, Rahmani F, Swisher L, Wang Q, Allegri RF, Berman SB, Brickman AM, Brooks WS, Cash DM, Chhatwal JP, Day GS, Farlow MR, la Fougère C, Fox NC, Fulham M, Ghetti B, Graff-Radford N, Ikeuchi T, Klunk W, Lee JH, Levin J, Martins R, Masters CL, McConathy J, Mori H, Noble JM, Reischl G, Rowe C, Salloway S, Sanchez-Valle R, Schofield PR, Shimada H, Shoji M, Su Y, Suzuki K, Vöglein J, Yakushev I, Cruchaga C, Hassenstab J, Karch C, McDade E, Perrin RJ, Xiong C, Morris JC, Bateman RJ, Benzinger TLS; Dominantly Inherited Alzheimer Network. Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nat Neurosci. 2023 Aug;26(8):1449-1460. doi: 10.1038/s41593-023-01359- 8. Epub 2023 Jul 10. PMID: 37429916; PMCID: PMC10400428
    6. Phillips B, Western D, Wang L, Timsina J, Sun Y, Gorijala P, Yang C, Do A, Nykänen NP, Alvarez I, Aguilar M, Pastor P, Morris JC, Schindler SE, Fagan AM, Puerta R, García-González P, de Rojas I, Marquié M, Boada M, Ruiz A, Perlmutter JS; Dominantly Inherited Alzheimer Network (DIAN) Consortia; Ibanez L, Perrin RJ, Sung YJ, Cruchaga C. Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease. NPJ Parkinsons Dis. 2023 Jul 8;9(1):107. doi: 10.1038/s41531-023-00555-4. PMID: 37422510; PMCID: PMC10329646.
    7. Sung YJ, Yang C, Norton J, Johnson M, Fagan A, Bateman RJ, Perrin RJ, Morris JC, Farlow MR, Chhatwal JP, Schofield PR, Chui H, Wang F, Novotny B, Eteleeb A, Karch C, Schindler SE, Rhinn H, Johnson ECB, Oh HS, Rutledge JE, Dammer EB, Seyfried NT, Wyss-Coray T, Harari O, Cruchaga C. Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer’s disease. Sci Transl Med. 2023 Jul 5;15(703):eabq5923. doi: 10.1126/scitranslmed.abq5923. Epub 2023 Jul 5. PMID: 37406134.
    8. Cruchaga C, Western D, Timsina J, Wang L, Wang C, Yang C, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey A, Morris J, Perrin R, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson E, Guen YL, Alvarez I, Aguilar M, Greicius M, Pastor P, Pulford D, Ibanez L, Wyss-Coray T, Sung YJ, Phillips B. Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer’s disease. Res Sq [Preprint]. 2023 Jun 9:rs.3.rs-2814616. doi: 10.21203/rs.3.rs- 2814616/v1. PMID: 37333337; PMCID: PMC10275048.
    9. Wang C, Western D, Yang C, Ali M, Wang L, Gorijala P, Timsina J, Ruiz A, Pastor P, Fernandez M, Panyard D, Engelman C, Deming Y, Boada M, Cano A, García- González P, Graff-Radford N, Mori H, Lee JH, Perrin R, Sung YJ, Dian DIAN, Adni ADNI, Cruchaga C. Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness. Res Sq [Preprint]. 2023 Jun 9:rs.3.rs-2923409. doi: 10.21203/rs.3.rs-2923409/v1. PMID: 37333177; PMCID: PMC10274943.
    10. Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, Berman S, Chui HC, Fagan AM, Farlow MR, Fox NC, Gordon BA, Day GS, Graff-Radford NR, Hassenstab JJ, Hanseeuw BJ, Hofmann A, Jack CR Jr, Jucker M, Karch CM, Koeppe RA, Lee JH, Levey AI, Levin J, Martins RN, Mori H, Morris JC, Noble J, Perrin RJ, Rosa-Neto P, Salloway SP, Sanchez-Valle R, Schofield PR, Xiong C, Johnson KA, Bateman RJ, Sperling RA, Chhatwal JP; Dominantly Inherited Alzheimer Network Investigators. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal- dominant Alzheimer’s disease. Aging Cell. 2023 Aug;22(8):e13871. doi: 10.1111/acel.13871. Epub 2023 Jun 8. PMID: 37291760; PMCID: PMC10410059.
    11. O’Connor A, Cash DM, Poole T, Markiewicz PJ, Fraser MR, Malone IB, Jiao J, Weston PSJ, Flores S, Hornbeck R, McDade E, Schöll M, Gordon BA, Bateman RJ, Benzinger TLS, Fox NC. Tau accumulation in autosomal dominant Alzheimer’s disease: a longitudinal [18F]flortaucipir study. Alzheimers Res Ther. 2023 May 25;15(1):99. doi: 10.1186/s13195-023-01234-5. PMID: 37231491; PMCID: PMC10210376.
    12. Timsina J, Ali M, Do A, Wang L, Sung YJ, Cruchaga C. Harmonization of CSF and imaging biomarkers for Alzheimer’s disease biomarkers: need and practical applications for genetics studies and preclinical classification. bioRxiv [Preprint]. 2023 May 24:2023.05.24.542118. doi: 10.1101/2023.05.24.542118. PMID: 37292823; PMCID: PMC10245826.
    13. Luo J, Ma Y, Agboola FJ, Grant E, Morris JC, McDade E, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Gordon BA, Goyal M, Strain JF, Yakushev I, Day GS, Xiong C; for Dominantly Inherited Alzheimer Network (DIAN). Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Life Span. Neurology. 2023 Jul 11;101(2):e164-e177. doi: 10.1212/WNL.0000000000207378. Epub 2023 May 18. PMID: 37202169; PMCID: PMC10351551.
    14. O’Connor A, Rice H, Barnes J, Ryan NS, Liu KY, Allegri RF, Berman S, Ringman JM, Cruchaga C, Farlow MR, Hassenstab J, Lee JH, Perrin RJ, Xiong C, Gordon B, Levey AI, Goate A, Graff-Radford N, Levin J, Jucker M, Benzinger T, McDade E, Mori H, Noble JM, Schofield PR, Martins RN, Salloway S, Chhatwal J, Morris JC, Bateman R, Howard R, Reeves S, Fox NC. First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease: the Dominantly Inherited Alzheimer’s Network Study. Journal of Neurology, Neurosurgery, and Psychiatry. 2023 May;94(5):403-405. PubMed PMID: 36522155; DOI: 10.1136/jnnp-2022-329843.
    15. Ali M, Archer DB, Gorijala P, Western D, Timsina J, Fernández MV, Wang TC, Satizabal CL, Yang Q, Beiser AS, Wang R, Chen G, Gordon B, Benzinger TLS, Xiong C, Morris JC, Bateman RJ, Karch CM, McDade E, Goate A, Seshadri S, Mayeux RP, Sperling RA, Buckley RF, Johnson KA, Won HH, Jung SH, Kim HR, Seo SW, Kim HJ, Mormino E, Laws SM, Fan KH, Kamboh MI, Vemuri P, Ramanan VK, Yang HS, Wenzel A, Rajula HSR, Mishra A, Dufouil C, Debette S, Lopez OL, DeKosky ST, Tao F, Nagle MW; Knight Alzheimer Disease Research Center (Knight ADRC); Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); ADNI-DOD, A4 Study Team; Australian Imaging Biomarkers, Lifestyle (AIBL) Study; Hohman TJ, Sung YJ, Dumitrescu L, Cruchaga C. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. Acta Neuropathol Commun. 2023 Apr 26;11(1):68. doi: 10.1186/s40478-023- 01563-4. PMID: 37101235; PMCID: PMC10134547.
    16. Brase L, You SF, D’Oliveira Albanus R, Del-Aguila JL, Dai Y, Novotny BC, Soriano-Tarraga C, Dykstra T, Fernandez MV, Budde JP, Bergmann K, Morris JC, Bateman RJ, Perrin RJ, McDade E, Xiong C, Goate AM, Farlow M; Dominantly Inherited Alzheimer Network (DIAN); Sutherland GT, Kipnis J, Karch CM, Benitez BA, Harari O. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nat Commun. 2023 Apr 21;14(1):2314. doi: 10.1038/s41467-023-37437-5. PMID: 37085492; PMCID: PMC10121712
    17. Aschenbrenner, AJ, Hassenstab, J, Morris, JC, Cruchaga, C, Jackson, JJ. Relationship between hourly cognitive variability and risk of Alzheimer disease revealed with mixed effects location scale models. Neuropsychology. 2023 Apr 20: 10.1037/neu0000905. doi: 10.1037/neu0000905.PMID: 37079810; PMCID: PMC10587364
    18. Schindler SE, Li Y, Li M, Despotis A, Park E, Vittert L, Hamilton BH, Womack KB, Saef B, Holtzman DM, Morris JC, Bateman RJ, Gupta MR. Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2023 April;19(4):1175-1183. PubMed PMID: 35934777; PubMed Central PMCID: PMC9902574; DOI: 10.1002/alz.12754.
    19. Chen CD, McCullough A, Gordon B, Joseph-Mathurin N, Flores S, McKay NS, Hobbs DA, Hornbeck R, Fagan AM, Cruchaga C, Goate AM, Perrin RJ, Wang G, Li Y, Shi X, Xiong C, Pontecorvo MJ, Klein G, Su Y, Klunk WE, Jack C, Koeppe R, et al. Longitudinal head-to-head comparison of (11)C-PiB and (18)F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2023 Apr 5. doi: 10.1007/s00259-023-06209-0. [Epub ahead of print] PubMed [citation] PMID: 37017737; PMCID: PMC10330155
    20. Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton- Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, Anderson AG, Rodriguez-Nunez I, Roberts K, Dominantly Inherited Alzheimer Network, Absher D, Myers RM, Beecham GW, Reitz C, Rizzardi LF, Fernandez MV, Goate AM, Cruchaga C, Renton AE, Lopera F, Kosik KS. Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred. Alzheimers Dement. 2023 Mar 23. doi: 10.1002/alz.13021. Epub ahead of print. PMID: 36951251; PMCID: PMC10514237
    21. Vermunt L, Sutphen C, Dicks E, de Leeuw DM, Allegri R, Berman SB, Cash DM, Chhatwal JP, Cruchaga C, Day G, Ewers M, Farlow M, Fox NC, Ghetti B, Graff-Radford N, Hassenstab J, Jucker M, Karch CM, Kuhle J, Laske C, Levin J, Masters CL, McDade E, Mori H, Morris JC, Perrin RJ, Preische O, Schofield PR, Suárez- Calvet M, Xiong C, Scheltens P, Teunissen CE, Visser PJ, Bateman RJ, Benzinger TLS, Fagan AM, Gordon BA, Tijms BM. Axonal damage and astrocytosis are biological correlates of grey matter network integrity loss: a cohort study in autosomal dominant Alzheimer disease. medRxiv [Preprint]. 2023 Mar 22:2023.03.21.23287468. doi: 10.1101/2023.03.21.23287468. PMID: 37016671; PMCID: PMC10071836.
    22. Xu J, Farsad HL, Hou Y, Barclay K, Lopez BA, Yamada S, Saliu IO, Shi Y, Knight WC, Bateman RJ, Benzinger TLS, Yi JJ, Li Q, Wang T, Perlmutter JS, Morris JC, Zhao G. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration. Nature aging. 2023 March;3(3):346-365. PubMed PMID: 36993867; PubMed Central PMCID: PMC10046522; DOI: 10.1038/s43587-023-00363-8.
    23. Horie K, Li Y, Barthélemy NR, Gordon B, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, Farlow M, Chhatwal J, Day G, Schofield PR, Masters CL, Levin J, Jucker M, Lee JH, Roh JH, Sato C, Sachdev P, Koyama A, Reyderman L, Bateman RJ, McDade E. Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer’s Disease. Annals of Neurology. 2023 February 26. PubMed PMID: 36843330; DOI: 10.1002/ana.26620.
    24. You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D’Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E, Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv : the preprint server for health sciences. 2023 February 8. PubMed PMID: 36798226; PubMed Central PMCID: PMC9934804; DOI: 10.1101/2023.02.06.23285545.
    25. Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal JP, Salloway S, Xiong C, Karch CM, Cairns N, Perrin RJ, Day G, Martins R, Sanchez-Valle R, Mori H, Shimada H, Ikeuchi T, Suzuki K, Schofield PR, Masters CL, Goate A, Buckles V, Fox NC, Chrem P, Allegri R, Ringman JM, Yakushev I, Laske C, Jucker M, Höglinger G, Bateman RJ, Danek A, Levin J. Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2023 February; 19(2):632-645. PubMed PMID: 35609137; PubMed Central PMCID: PMC9684350; DOI: 10.1002/alz.12684..
    26. Xiong C, McCue LM, Buckles V, Grant E, Agboola F, Coble D, Bateman RJ, Fagan AM, Benzinger TLS, Hassenstab J, Schindler SE, McDade E, Moulder K, Gordon BA, Cruchaga C, Day GS, Ikeuchi T, Suzuki K, Allegri RF, Vöglein J, Levin J, Morris JC. Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January 14. PubMed PMID: 36640138; DOI: 10.1002/alz.12912.
    27. Millar PR, Gordon BA, Luckett PH, Benzinger TLS, Cruchaga C, Fagan AM, Hassenstab JJ, Perrin RJ, Schindler SE, Allegri RF, Day GS, Farlow MR, Mori H, Nübling G, Bateman RJ, Morris JC, Ances BM. Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study. eLife. 2023 January 6; 12. PubMed PMID: 36607335; PubMed Central PMCID: PMC9988262; DOI: 10.7554/eLife.81869.
    28. Luckett PH, Chen C, Gordon BA, Wisch J, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, Salloway S, Schofield PR, Brickman AM, Brooks WS, Cash DM, Fulham MJ, Ghetti B, Jack CR Jr, Vöglein J, Klunk WE, Koeppe R, Su Y, Weiner M, Wang Q, Marcus D, Koudelis D, Joseph-Mathurin N, Cash L, Hornbeck R, Xiong C, Perrin RJ, Karch CM, Hassenstab J, McDade E, Morris JC, Benzinger TLS, Bateman RJ, Ances BM. Biomarker clustering in autosomal dominant Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January; 19(1):274-284. PubMed PMID: 35362200; PubMed Central PMCID: PMC9525451; DOI: 10.1002/alz.12661.
    29. Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2023 January; 19(1):79-96. PubMed PMID: 35278341; PubMed Central PMCID: PMC9464800; DOI: 10.1002/alz.12646.
    30. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O’Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology. 2023 January; 22(1):55-65. PubMed PMID: 36517172; PubMed Central PMCID: PMC9979840; DOI: 10.1016/S1474-4422(22)00408-2.
    31. Wheelock MD, Strain JF, Mansfield P, Tu JC, Tanenbaum A, Preische O, Chhatwal JP, Cash DM, Cruchaga C, Fagan AM, Fox NC, Graff-Radford NR, Hassenstab J, Jack CR, Karch CM, Levin J, McDade EM, Perrin RJ, Schofield PR, Xiong C, Morris JC, Bateman RJ, Jucker M, Benzinger TLS, Ances BM, Eggebrecht AT, Gordon BA; Dominantly Inherited Alzheimer Network. Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease. Brain. 2023 Jan 10:awac498. doi: 10.1093/brain/awac498. Online ahead of print. PMID: 36625756; PMCID: PMC10316768.
    32. Chatterjee P, Vermunt L, Gordon BA, Pedrini S, Boonkamp L, Armstrong NJ, Xiong C, Singh AK, Li Y, Sohrabi HR, Taddei K, Molloy M, Benzinger TLS, Morris JC, Karch C, Berman S, Chhatwal J, Cruchaga C, Graff-Radford NR, Day GS, Farlow M, Fox N, Goate A, Hassenstab J, Lee JH, Levin J, McDade E, Mori H, Perrin R, Sanchez-Valle R, Schofield PR, Levey A, Jucker M, Masters CL, Fagan AM, Bateman RJ, Martins RN, Teunissen C. Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer’s disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2022 December 28. PubMed PMID: 36576155; DOI: 10.1002/alz.12879.
    33. Luo J, Agboola F, Grant E, Morris JC, Masters CL, Albert MS, Johnson SC, McDade EM, Fagan AM, Benzinger TLS, Hassenstab J, Bateman RJ, Perrin RJ, Wang G, Li Y, Gordon B, Cruchaga C, Day GS, Levin J, Vöglein J, Ikeuchi T, Suzuki K, Allegri RF, Xiong C. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022 December 19; 145(12):4459-4473. PubMed PMID: 35925685; DOI: 10.1093/brain/awac238.
    34. Rother C, Uhlmann RE, Müller SA, Schelle J, Skodras A, Obermüller U, Häsler LM, Lambert M, Baumann F, Xu Y, Bergmann C, Salvadori G, Loos M, Brzak I, Shimshek D, Neumann U, Walker LC, Schultz SA, Chhatwal JP, Kaeser SA, Lichtenthaler SF, Staufenbiel M, Jucker M. Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae. Nature communications. 2022 November 28;13(1):7333. PubMed PMID: 36443293; PubMed Central PMCID: PMC9705543; DOI: 10.1038/s41467-022-34538-5.
    35. Strain JF, Brier MR, Tanenbaum A, Gordon BA, McCarthy JE, Dincer A, Marcus DS, Chhatwal JP, Graff-Radford NR, Day GS, la Fougère C, Perrin RJ, Salloway S, Schofield PR, Yakushev I, Ikeuchi T, Vöglein J, Morris JC, Benzinger TLS, Bateman RJ, Ances BM, Snyder AZ. Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease. NeuroImage. 2022 November 1; 261:119511. PubMed PMID: 35914670; PubMed Central PMCID: PMC9750733; DOI: 10.1016/j.neuroimage.2022.119511.
    36. Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, Chhatwal J, Hu S, Randolph GJ, Smirnov I, Kipnis J. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature. 2022 November; 611(7936):585-593. PubMed PMID: 36352225; PubMed Central PMCID: PMC9899827; DOI: 10.1038/s41586-022-05397-3.
    37. Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, Fagan AM, Farlow M, Fox NC, Ghetti B, Goate AM, Gordon BA, Graff-Radford N, Day GS, Hassenstab J, Ikeuchi T, Jack CR, Jagust WJ, Jucker M, Levin J, Massoumzadeh P, Masters CL, Martins R, McDade E, Mori H, Noble JM, Petersen RC, Ringman JM, Salloway S, Saykin AJ, Schofield PR, Shaw LM, Toga AW, Trojanowski JQ, Vöglein J, Weninger S, Bateman RJ, Buckles VD. Autosomal dominant and sporadic late onset Alzheimer’s disease share a common in vivo pathophysiology. Brain: a journal of neurology. 2022 October 21;145(10):3594-3607. PubMed PMID: 35580594; PubMed Central PMCID: PMC9989348; DOI: 10.1093/brain/awac181.
    38. Novotny BC, Fernandez MV, Wang C, Budde JP, Bergmann K, Eteleeb AM, Bradley J, Webster C, Ebl C, Norton J, Gentsch J, Dube U, Wang F, Morris JC, Bateman RJ, Perrin RJ, McDade E, Xiong C, Chhatwal J, Goate A, Farlow M, Schofield P, Chui H, Karch CM, Cruchaga C, Benitez BA, Harari O. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer’s disease brains. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2022 October 17. PubMed PMID: 36251323; PubMed Central PMCID: PMC10106526; DOI: 10.1002/alz.12800.
    39. Li F, Eteleeb AM, Buchser W, Sohn C, Wang G, Xiong C, Payne PR, McDade E, Karch CM, Harari O, Cruchaga C. Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease. Front Aging Neurosci. 2022 Sep 27;14:935279. doi: 10.3389/fnagi.2022.935279. PMID: 36238934; PMCID: PMC9551568.
    40. Nicosia J, Aschenbrenner AJ, Balota DA, Sliwinski MJ, Tahan M, Adams S, Stout SS, Wilks H, Gordon BA, Benzinger TLS, Fagan AM, Xiong C, Bateman RJ, Morris JC, Hassenstab J. Unsupervised high-frequency smartphone-based cognitive assessments are reliable, valid, and feasible in older adults at risk for Alzheimer’s disease. Journal of the International Neuropsychological Society : JINS. 2022 September 5:1-13. PubMed PMID: 36062528; PubMed Central PMCID: PMC9985662; DOI: 10.1017/S135561772200042X.
    41. Shirzadi Z, Yau WW, Schultz SA, Schultz AP, Scott MR, Goubran M, Mojiri-Forooshani P, Joseph-Mathurin N, Kantarci K, Preboske G, Wermer MJH, Jack C, Benzinger T, Taddei K, Sohrabi HR, Sperling RA, Johnson KA, Bateman RJ, Martins RN, Greenberg SM, Chhatwal JP. Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy. Annals of neurology. 2022 September; 92(3):358-363. PubMed PMID: 35670654; PubMed Central PMCID: PMC9391284; DOI: 10.1002/ana.26429.
    42. Nicosia J, Wang B, Aschenbrenner AJ, Sliwinski MJ, Yabiku ST, Roque NA, Germine LT, Bateman RJ, Morris JC, Hassenstab J. To BYOD or not: Are device latencies important for bring-your-own-device (BYOD) smartphone cognitive testing?. Behavior research methods. 2022 August 11. PubMed PMID: 35953659; PubMed Central PMCID: PMC9918597; DOI: 10.3758/s13428-022-01925-1.
    43. Takada LT, Aláez-Verson C, Burgute BD, Nitrini R, Sosa AL, Castilhos RM, Chaves MF, Longoria EM, Carrillo-Sánchez K, Brucki SMD, Flores-Lagunes LL, Molina C, Olivares MJ, Ziegemeier E, Petranek J, Goate AM, Cruchaga C, Renton AE, Fernández MV, Day GS, McDade E, Bateman RJ, Karch CM, Llibre-Guerra JJ. Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America. Alzheimer’s research & therapy. 2022 August 5;14(1):108. PubMed PMID: 35932032; PubMed Central PMCID: PMC9354296; DOI: 10.1186/s13195-022-01052-1.
    44. Millar PR, Luckett PH, Gordon BA, Benzinger TLS, Schindler SE, Fagan AM, Cruchaga C, Bateman RJ, Allegri R, Jucker M, Lee JH, Mori H, Salloway SP, Yakushev I, Morris JC, Ances BM. Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease. NeuroImage. 2022 August 1;256:119228. PubMed PMID: 35452806; PubMed Central PMCID: PMC9178744; DOI: 10.1016/j.neuroimage.2022.119228.
    45. Strain JF, Barthelemy N, Horie K, Gordon BA, Kilgore C, Aschenbrenner A, Cruchaga C, Xiong C, Joseph-Mathurin N, Hassenstab J, Fagan AM, Li Y, Karch CM, Perrin RJ, Berman SB, Chhatwal JP, Graff-Radford NR, Mori H, Levin J, Noble JM, Allegri R, Schofield PR, Marcus DS, Holtzman DM, Morris JC, Benzinger TLS, McDade EM, Bateman RJ, Ances BM. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease. Neurobiology of disease. 2022 June 15;168:105714. PubMed PMID: 35358703; PubMed Central PMCID: PMC9701560; DOI: 10.1016/j.nbd.2022.105714.
    46. Meeker KL, Butt OH, Gordon BA, Fagan AM, Schindler SE, Morris JC, Benzinger TLS, Ances BM. Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage. Neurobiology of disease. 2022 May;166:105662. PubMed PMID: 35167933; PubMed Central PMCID: PMC9112943; DOI: 10.1016/j.nbd.2022.105662.
    47. Nicosia J, Aschenbrenner AJ, Adams SL, Tahan M, Stout SH, Wilks H, Balls-Berry JE, Morris JC, Hassenstab J. Bridging the Technological Divide: Stigmas and Challenges With Technology in Digital Brain Health Studies of Older Adults. Frontiers in digital health. 2022;4:880055. PubMed PMID: 35574256; PubMed Central PMCID: PMC9098948; DOI: 10.3389/fdgth.2022.880055.
    48. Levitis E, Vogel JW, Funck T, Hachinski V, Gauthier S, Vöglein J, Levin J, Gordon BA, Benzinger T, Iturria-Medina Y, Evans AC. Differentiating amyloid beta spread in autosomal dominant and sporadic Alzheimer’s disease. Brain communications. 2022;4(3):fcac085. PubMed PMID: 35602652; PubMed Central PMCID: PMC9116976; DOI: 10.1093/braincomms/fcac085.
    49. Ali M, Sung YJ, Wang F, Fernández MV, Morris JC, Fagan AM, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleó A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Haass C, Ewers M, Levin J, Farlow MR, Perrin RJ, Cruchaga C. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. PloS one. 2022;17(5):e0267298. PubMed PMID: 35617280; PubMed Central PMCID: PMC9135221; DOI: 10.1371/journal.pone.0267298.
    50. Aschenbrenner AJ, Hassenstab J, Wang G, Li Y, Xiong C, McDade E, Clifford DB, Salloway S, Farlow M, Yaari R, Cheng EYJ, Holdridge KC, Mummery CJ, Masters CL, Hsiung GY, Surti G, Day GS, Weintraub S, Honig LS, Galvin JE, Ringman JM, Brooks WS, Fox NC, Snyder PJ, Suzuki K, Shimada H, Gräber S, Bateman RJ. Avoid or Embrace? Practice Effects in Alzheimer’s Disease Prevention Trials. Frontiers in aging neuroscience. 2022;14:883131. PubMed PMID: 35783127; PubMed Central PMCID: PMC9244171; DOI: 10.3389/fnagi.2022.883131.
    51. Wang G, Li Y, Xiong C, McDade E, Clifford DB, Mills SL, Santacruz AM, Aschenbrenner AJ, Hassenstab J, Benzinger TLS, Gordon BA, Fagan AM, Coalier KA, Libre-Guerra JJ, McCullough A, Joseph-Mathurin N, Chen CD, Mummery C, Wendelberger BA, Gauthier S, Masellis M, Holdridge KC, Yaari R, Chatterjee S, Sims J, Delmar P, Kerchner GA, Bittner T, Hofmann C, Bateman RJ. Evaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease. Alzheimer’s & dementia (Amsterdam, Netherlands). 2022;14(1):e12367. PubMed PMID: 36348972; PubMed Central PMCID: PMC9632865; DOI: 10.1002/dad2.12367.
    52. Timsina J, Gomez-Fonseca D, Wang L, Do A, Western D, Alvarez I, Aguilar M, Pastor P, Henson RL, Herries E, Xiong C, Schindler SE, Fagan AM, Bateman RJ, Farlow M, Morris JC, Perrin RJ, Moulder K, Hassenstab J, Vöglein J, Chhatwal J, Mori H, Sung YJ, Cruchaga C. Comparative Analysis of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach. Journal of Alzheimer’s disease : JAD. 2022;89(1):193-207. PubMed PMID: 35871346; PubMed Central PMCID: PMC9562128; DOI: 10.3233/JAD-220399.
    53. Luo J, Gao F, Liu J, Wang G, Chen L, Fagan AM, Day GS, Vöglein J, Chhatwal JP, Xiong C. Statistical estimation and comparison of group-specific bivariate correlation coefficients in family-type clustered studies. Journal of Applied Statistics. 2022; 49(9):2246-2270. PubMed PMID: 35755087; PubMed Central PMCID: PMC9225315; DOI:10.1080/02664763.2021. 1899141.
    54. McKay NS, Dincer A, Mehrotra V, Aschenbrenner AJ, Balota D, Hornbeck RC, Hassenstab J, Morris JC, Benzinger TLS, Gordon BA. Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults. Neurobiology of aging. Neurobiol Aging. 2022 Apr;112:181-190. doi: 10.1016/j.neurobiolaging.2021.12.012. Epub 2022 Jan 10. PMID: 35227946.
    55. Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer’s disease: a longitudinal observational study. The Lancet. Neurology. 2022 April;21(4):329-341. PubMed PMID: 35305339; PubMed Central PMCID: PMC8926925; DOI: 10.1016/S1474-4422(22)00027-8.
    56. Chen HH, Eteleeb A, Wang C, Fernandez MV, Budde JP, Bergmann K, Norton J, Wang F, Ebl C, Morris JC, Perrin RJ, Bateman RJ, McDade E, Xiong C, Goate A, Farlow M, Chhatwal J, Schofield PR, Chui H, Harari O, Cruchaga C, Ibanez L. Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer’s disease. Acta neuropathologica communications. 2022 March 4;10(1):29. PubMed PMID: 35246267; PubMed Central PMCID: PMC8895634; DOI: 10.1186/s40478-022-01328-5.
    57. Lim YY, Maruff P, Barthélemy NR, Goate A, Hassenstab J, Sato C, Fagan AM, Benzinger TLS, Xiong C, Cruchaga C, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield PR, Morris JC, Bateman RJ, McDade E. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. JAMA neurology. 2022 March 1;79(3):261-270. PubMed PMID: 35099506; PubMed Central PMCID: PMC8804973; DOI: 10.1001/jamaneurol.2021.5181.
    58. Raman F, Fang YD, Grandhi S, Murchison CF, Kennedy RE, Morris JC, Massoumzadeh P, Benzinger T, Roberson ED, McConathy J. Dynamic Amyloid PET: Relationships to 18FFlortaucipir Tau PET Measures. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022 February;63(2):287-293. PubMed PMID: 34049986; PubMed Central PMCID: PMC8805772; DOI: 10.2967/jnumed.120.254490.
    59. Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, Sung YJ, Lee JH, Klunk WE, Hofmann A, Noble JM, Graff-Radford N, Mori H, Salloway SM, Masters CL, Martins R, Karch CM, Xiong C, Cruchaga C, Perrin RJ, Gordon BA, Benzinger TLS, Fox NC, Schofield PR, Fagan AM, Goate AM, Morris JC, Bateman RJ, Johnson KA, Sperling RA. Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer’s disease: cross-sectional and longitudinal analyses of an observational study. The Lancet. Neurology. 2022 February;21(2):140-152. PubMed PMID: 35065037; PubMed Central PMCID: PMC8956209; DOI: 10.1016/S1474-4422(21)00375-6.
    60. Hubbard EE, Heil LR, Merrihew GE, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Bateman RJ, Larson EB, Keene CD, Perrin RJ, Montine TJ, MacCoss MJ, Julian RR. Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease. Journal of proteome research. 2022 January 7;21(1):118-131. PubMed PMID: 34818016; PubMed Central PMCID: PMC8741752; DOI:10.1021/acs.jproteome.1c00558.
    61. Koenig LN, LaMontagne P, Glasser MF, Bateman R, Holtzman D, Yakushev I, Chhatwal J, Day GS, Jack C, Mummery C, Perrin RJ, Gordon BA, Morris JC, Shimony JS, Benzinger TLS. Regional age-related atrophy after screening for preclinical alzheimer disease. Neurobiology of aging. 2022 January;109:43-51. PubMed PMID: 34655980; PubMed Central PMCID: PMC9009406; DOI: 10.1016/j.neurobiolaging.2021.09.010.
    62. Buckles VD, Xiong C, Bateman RJ, Hassenstab J, Allegri R, Berman SB, Chhatwal JP, Danek A, Fagan AM, Ghetti B, Goate A, Graff-Radford N, Jucker M, Levin J, Marcus DS, Masters CL, McCue L, McDade E, Mori H, Moulder KL, Noble JM, Paumier K, Preische O, Ringman JM, Fox NC, Salloway S, Schofield PR, Martins R, Vöglein J, Morris JC. Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2021 December 2. PubMed PMID: 34854530; DOI: 10.1002/alz.12505.
    63. Therneau TM, Knopman DS, Lowe VJ, Botha H, Graff-Radford J, Jones DT, Vemuri P, Mielke MM, Schwarz CG, Senjem ML, Gunter JL, Petersen RC, Jack CR Jr. Relationships between β-amyloid and tau in an elderly population: An accelerated failure time model. NeuroImage. 2021 November 15;242:118440. PubMed PMID: 34333107; PubMed Central PMCID: PMC8499700; DOI: 10.1016/j.neuroimage.2021.118440.
    64. Lucey BP, Wisch J, Boerwinkle AH, Landsness EC, Toedebusch CD, McLeland JS, Butt OH, Hassenstab J, Morris JC, Ances BM, Holtzman DM. Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer’s disease. Brain : a journal of neurology. 2021 October 22;144(9):2852-2862. PubMed PMID: 34668959; PubMed Central PMCID: PMC8536939; DOI: 10.1093/brain/awab272.
    65. Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, Xiong C, Bateman RJ, Ghetti B, Ringman JM, Chhatwal J, Masters CL, McLean C, Lashley T, Su Y, Koeppe R, Jack C, Klunk WE, Morris JC, Perrin RJ, Cairns NJ, Benzinger TLS. Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta neuropathologica. 2021 October;142(4):689-706. PubMed PMID: 34319442; PubMed Central PMCID: PMC8815340; DOI: 10.1007/s00401-021-02342-y.
    66. Wilks H, Aschenbrenner AJ, Gordon BA, Balota DA, Fagan AM, Musiek E, Balls-Berry J, Benzinger TLS, Cruchaga C, Morris JC, Hassenstab J. Sharper in the morning: Cognitive time of day effects revealed with high-frequency smartphone testing. Journal of clinical and experimental neuropsychology. 2021 October; 43(8):825-837. PubMed PMID: 35037593; PubMed Central PMCID: PMC9116128; DOI: 10.1080/13803395.2021.2009447.
    67. Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, Gauthier S, Benzinger TLS, Morris JC, Bateman RJ, Breitner JCS, Poirier J, Vachon-Presseau E, Villeneuve S. Accelerated functional brain aging in preclinical familial Alzheimer’s disease. Nature communications. 2021 September 9;12(1):5346.
      PubMed PMID: 34504080; PubMed Central PMCID: PMC8429427; DOI: 10.1038/s41467-021- 25492-9.
    68. Zhou Y, Flores S, Mansor S, Hornbeck RC, Tu Z, Perlmutter JS, Ances B, Morris JC, Gropler RJ, Benzinger TLS. Spatially constrained kinetic modeling with dual reference tissues improves 18F-flortaucipir PET in studies of Alzheimer disease. European journal of nuclear medicine and molecular imaging. 2021 September;48(10):3172-3186. PubMed PMID: 33599811; PubMed Central PMCID: PMC8371062; DOI: 10.1007/s00259-020-05134-w.
    69. Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, Hassenstab J, Gordon BA, Chhatwal JP, Levin J, Schofield P, Benzinger TLS, Morris JC, Goate A, Karch CM, Fagan AM, McDade E, Allegri R, Berman S, Chui H, Cruchaga C, Farlow M, Graff-Radford N, Jucker M, Lee JH, Martins RN, Mori H, Perrin R, Xiong C, Rossor M, Fox NC, O’Connor A, Salloway S, Danek A, Buerger K, Bateman RJ, Habeck C, Stern Y, Franzmeier N. Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease. Brain: a journal of neurology. 2021 August 17;144(7):2176-2185. PubMed PMID: 33725114; PubMed Central PMCID: PMC8370409; DOI: 10.1093/brain/awab112.
    70. Fagan AM, Henson RL, Li Y, Boerwinkle AH, Xiong C, Bateman RJ, Goate A, Ances BM, Doran E, Christian BT, Lai F, Rosas HD, Schupf N, Krinsky-McHale S, Silverman W, Lee JH, Klunk WE, Handen BL, Allegri RF, Chhatwal JP, Day GS, Graff-Radford NR, Jucker M, Levin J, Martins RN, Masters CL, Mori H, Mummery CJ, Niimi Y, Ringman JM, Salloway S, Schofield PR, Shoji M, Lott IT. Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer’s disease: a cross-sectional study. The Lancet. Neurology. 2021 August;20(8):615-626. PubMed PMID: 34302786; PubMed Central PMCID: PMC8496347; DOI: 10.1016/S1474-4422(21)00139-3.
    71. McDade E, Llibre-Guerra JJ, Holtzman DM, Morris JC, Bateman RJ. The informed road map to prevention of Alzheimer Disease: A call to arms. Molecular neurodegeneration. 2021 July 21;16(1):49. PubMed PMID: 34289882; PubMed Central PMCID: PMC8293489; DOI: 10.1186/s13024-021-00467-y.
    72. Salloway S, Farlow M, McDade E, Clifford DB, Wang G, Llibre-Guerra JJ, Hitchcock JM, Mills SL, Santacruz AM, Aschenbrenner AJ, Hassenstab J, Benzinger TLS, Gordon BA, Fagan AM, Coalier KA, Cruchaga C, Goate AA, Perrin RJ, Xiong C, Li Y, Morris JC, Snider BJ, Mummery C, Surti GM, Hannequin D, Wallon D, Berman SB, Lah JJ, Jimenez-Velazquez IZ, Roberson ED, van Dyck CH, Honig LS, Sánchez-Valle R, Brooks WS, Gauthier S, Galasko DR, Masters CL, Brosch JR, Hsiung GR, Jayadev S, Formaglio M, Masellis M, Clarnette R, Pariente J, Dubois B, Pasquier F, Jack CR Jr, Koeppe R, Snyder PJ, Aisen PS, Thomas RG, Berry SM, Wendelberger BA, Andersen SW, Holdridge KC, Mintun MA, Yaari R, Sims JR, Baudler M, Delmar P, Doody RS, Fontoura P, Giacobino C, Kerchner GA, Bateman RJ. A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease. Nature medicine. 2021 July;27(7):1187-1196. PubMed PMID: 34155411; PubMed Central PMCID: PMC8988051; DOI: 10.1038/s41591-021-01369-8.
    73. Chen Y, Ying C, Binkley MM, Juttukonda MR, Flores S, Laforest R, Benzinger TLS, An H. Deep learning-based T1-enhanced selection of linear attenuation coefficients (DL-TESLA) for PET/MR attenuation correction in dementia neuroimaging. Magnetic resonance in medicine. 2021 July;86(1):499-513. PubMed PMID: 33559218; PubMed Central PMCID: PMC8091494; DOI: 10.1002/mrm.28689.
    74. Day GS, Yarbrough MY, Körtvelyessy P, Prüss H, Bucelli RC, Fritzler MJ, Mason W, Tang-Wai DF, Steriade C, Hébert J, Henson RL, Herries EM, Ladenson JH, Lopez Chiriboga AS, Graff-Radford NR, Morris JC, Fagan A. Prospective Quantification of CSF Biomarkers in Antibody-Mediated Encephalitis. Neurology. 2021 May 18;96(20):e2546-e2557. PubMed PMID: 33795390; PubMed Central PMCID: PMC8205475; DOI: 10.1212/WNL.0000000000011937.
    75. Pichet Binette A, Theaud G, Rheault F, Roy M, Collins DL, Levin J, Mori H, Lee JH, Farlow MR, Schofield P, Chhatwal JP, Masters CL, Benzinger T, Morris J, Bateman R, Breitner JC, Poirier J, Gonneaud J, Descoteaux M, Villeneuve S. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer’s disease. eLife. 2021 May 13;10. PubMed PMID: 33983116; PubMed Central PMCID: PMC8169107; DOI:10.7554/eLife.62929.
    76. Hernández D, Morgan Schlicht S, Daniszewski M, Karch CM, Goate AM, Pébay A. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer’s disease iPSC line carrying the London mutation in APP (V717I). Stem cell research. 2021 May; 53:102373. PubMed PMID: 34088002; PubMed Central PMCID: PMC10084742; DOI: 10.1016/j.scr.2021.102373.
    77. Martin WRW, Miles M, Zhong Q, Hartlein J, Racette BA, Norris SA, Ushe M, Maiti B, Criswell S, Davis AA, Kotzbauer PT, Cairns NJ, Perrin RJ, Perlmutter JS. Is Levodopa Response a Valid Indicator of Parkinson’s Disease?. Movement disorders : official journal of the Movement Disorder Society. 2021 April;36(4):948-954. PubMed PMID: 33253432; PubMed Central PMCID: PMC8046721; DOI: 10.1002/mds.28406.
    78. Liu J, Xiong C, Liu L, Wang G, Jingqin L, Gao F, Chen L, Li Y. Relative efficiency of equal versus unequal cluster sizes in cluster randomized trials with a small number of clusters. Journal of biopharmaceutical statistics. 2021 March;31(2):191-206. PubMed PMID: 32970522; PubMed Central PMCID: PMC8734433; DOI: 10.1080/10543406.2020.1814795.
    79. Pannee J, Shaw LM, Korecka M, Waligorska T, Teunissen CE, Stoops E, Vanderstichele HMJ, Mauroo K, Verberk IMW, Keshavan A, Pesini P, Sarasa L, Pascual-Lucas M, Fandos N, Allué JA, Portelius E, Andreasson U, Yoda R, Nakamura A, Kaneko N, Yang SY, Liu HC, Palme S, Bittner T, Mawuenyega KG, Ovod V, Bollinger J, Bateman RJ, Li Y, Dage JL, Stomrud E, Hansson O, Schott JM, Blennow K, Zetterberg H. The global Alzheimer’s Association round robin study on plasma amyloid β methods. Alzheimer’s & dementia (Amsterdam, Netherlands). 2021;13(1):e12242. PubMed PMID: 34692980; PubMed Central PMCID: PMC8515356; DOI: 10.1002/dad2.12242.
    80. Keret O, Staffaroni AM, Ringman JM, Cobigo Y, Goh SM, Wolf A, Allen IE, Salloway S, Chhatwal J, Brickman AM, Reyes-Dumeyer D, Bateman RJ, Benzinger TLS, Morris JC, Ances BM, Joseph-Mathurin N, Perrin RJ, Gordon BA, Levin J, Vöglein J, Jucker M, la Fougère C, Martins RN, Sohrabi HR, Taddei K, Villemagne VL, Schofield PR, Brooks WS, Fulham M, Masters CL, Ghetti B, Saykin AJ, Jack CR, Graff-Radford NR, Weiner M, Cash DM, Allegri RF, Chrem P, Yi S, Miller BL, Rabinovici GD, Rosen HJ; Dominantly Inherited Alzheimer Network. Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer’s disease. Alzheimer’s & dementia (Amsterdam, Netherlands). 2021;13(1):e12197. PubMed PMID: 34258377; PubMed Central PMCID: PMC8256623; DOI:10.1002/dad2.12197.
    81. Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease. Mol Psychiatry. 2021 Feb;26(2):614-628. doi: 10.1038/s41380-019-0404-6. Epub 2019 Mar 21. PubMed PMID: 30899092; PubMed Central PMCID: PMC6754794.
    82. Chatterjee P, Fagan AM, Xiong C, McKay M, Bhatnagar A, Wu Y, Singh AK, Taddei K, Martins I, Gardener SL, Molloy MP, Multhaup G, Masters CL, Schofield PR, Benzinger TLS, Morris JC, Bateman RJ, Greenberg SM, Wermer MJH, van Buchem MA, Sohrabi HR, Martins RN. Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations. J Alzheimers Dis. 2021;79(2):895-903. doi: 10.3233/JAD-201267. PubMed PMID: 33361604.
    83. Luo J, Agboola F, Grant E, Masters CL, Albert MS, Johnson SC, McDade EM, Vöglein J, Fagan AM, Benzinger T, Massoumzadeh P, Hassenstab J, Bateman RJ, Morris JC, Perrin RJ, Chhatwal J, Jucker M, Ghetti B, Cruchaga C, Graff-Radford NR, Schofield PR, Mori H, Xiong C. Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study. Neurology. 2020 Dec 8;95(23):e3104-e3116. doi: 10.1212/WNL.0000000000010747. Epub 2020 Sep 1. PubMed PMID: 32873693; PubMed Central PMCID: PMC7734923.
    84. Finsterwalder S, Vlegels N, Gesierich B, Araque Caballero MÁ, Weaver NA, Franzmeier N, Georgakis MK, Konieczny MJ, Koek HL, Karch CM, Graff-Radford NR, Salloway S, Oh H, Allegri RF, Chhatwal JP, Jessen F, Düzel E, Dobisch L, Metzger C, Peters O, Incesoy EI, Priller J, Spruth EJ, Schneider A, Fließbach K, Buerger K, Janowitz D, Teipel SJ, Kilimann I, Laske C, Buchmann M, Heneka MT, Brosseron F, Spottke A, Roy N, Ertl-Wagner B, Scheffler K, Seo SW, Kim Y, Na DL, Kim HJ, Jang H, Ewers M, Levin J, Schmidt R, Pasternak O, Dichgans M, Biessels GJ, Duering M. Small vessel disease more than Alzheimer’s disease determines diffusion MRI alterations in memory clinic patients. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2020 November;16(11):1504-1514. PubMed PMID: 32808747; PubMed Central PMCID: PMC8102202; DOI: 10.1002/alz.12150.
    85. Montal V, Vilaplana E, Pegueroles J, Bejanin A, Alcolea D, Carmona-Iragui M, Clarimón J, Levin J, Cruchaga C, Graff-Radford NR, Noble JM, Lee JH, Allegri R, Karch CM, Laske C, Schofield PR, Salloway S, Ances B, Benzinger T, McDale E, Bateman R, Blesa R, Sánchez-Valle R, Lleó A, Fortea J. Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2020 Nov 16;. doi: 10.1002/alz.12224. [Epub ahead of print] PubMed PMID: 33196147.
    86. Chen CD, Holden TR, Gordon BA, Franklin EE, Li Y, Coble DW, Luo H, Bateman RJ, Ances BM, Perrin RJ, Benzinger TLS, Cairns NJ, Morris JC. Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer’s disease. Ann Clin Transl Neurol. 2020 Nov 5;. doi: 10.1002/acn3.51237. [Epub ahead of print] PubMed PMID: 33150749; PubMed Central PMCID: PMC7732239.
    87. Gonneaud J, Bedetti C, Pichet Binette A, Benzinger TLS, Morris JC, Bateman RJ, Poirier J, Breitner JCS, Villeneuve S. Association of education with Aβ burden in preclinical familial and sporadic Alzheimer disease. Neurology. 2020 Sep 15;95(11):e1554-e1564. doi: 10.1212/WNL.0000000000010314. Epub 2020 Aug 5. PubMed PMID: 32759192; PubMed Central PMCID: PMC7713743.
    88. Vermunt L, Dicks E, Wang G, Dincer A, Flores S, Keefe SJ, Berman SB, Cash DM, Chhatwal JP, Cruchaga C, Fox NC, Ghetti B, Graff-Radford NR, Hassenstab J, Karch CM, Laske C, Levin J, Masters CL, McDade E, Mori H, Morris JC, Noble JM, Perrin RJ, Schofield PR, Xiong C, Scheltens P, Visser PJ, Bateman RJ, Benzinger TLS, Tijms BM, Gordon BA. Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer’s disease. Brain Commun. 2020;2(2):fcaa102. doi: 10.1093/braincomms/fcaa102. eCollection 2020. PubMed PMID: 32954344; PubMed Central PMCID: PMC7475695.
    89. Hsu S, Pimenova AA, Hayes K, Villa JA, Rosene MJ, Jere M, Goate AM, Karch CM. Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2. Neurobiol Dis. 2020 Jun;139:104817. doi: 10.1016/j.nbd.2020.104817. Epub 2020 Feb 19. PubMed PMID: 32087291; PubMed Central PMCID: PMC7236786.
    90. Castillo-Barnes D, Su L, Ramírez J, Salas-Gonzalez D, Martinez-Murcia FJ, Illan IA, Segovia F, Ortiz A, Cruchaga C, Farlow MR, Xiong C, Graff-Radford NR, Schofield PR, Masters CL, Salloway S, Jucker M, Mori H, Levin J, Gorriz JM. Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning. Inf Fusion. 2020 Jun;58:153-167. doi: 10.1016/j.inffus.2020.01.001. Epub 2020 Jan 7. PubMed PMID: 32284705; PubMed Central PMCID: PMC7153760.
    91. Gordon BA. Neurofilaments in disease: what do we know?. Curr Opin Neurobiol. 2020 Apr;61:105-115. doi: 10.1016/j.conb.2020.02.001. Epub 2020 Mar 6. Review. PubMed PMID: 32151970; PubMed Central PMCID: PMC7198337.
    92. Barthélemy NR, Li Y, Joseph-Mathurin N, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Perrin RJ, Goate AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Berman SB, Ikeuchi T, Mori H, Shimada H, Shoji M, Suzuki K, Noble J, Farlow M, Chhatwal J, Graff-Radford NR, Salloway S, Schofield PR, Masters CL, Martins RN, O’Connor A, Fox NC, Levin J, Jucker M, Gabelle A, Lehmann S, Sato C, Bateman RJ, McDade E. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease. Nat Med. 2020 Mar;26(3):398-407. doi: 10.1038/s41591-020-0781-z. Epub 2020 Mar 11. PubMed PMID: 32161412; PubMed Central PMCID: PMC7309367.
    93. Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J, Gordon BA, Lim YY, Masters CL, Rossor M, Fox NC, O’Connor A, Chhatwal J, Salloway S, Danek A, Hassenstab J, Schofield PR, Morris JC, Bateman RJ, Ewers M. Predicting sporadic Alzheimer’s disease progression via inherited Alzheimer’s disease-informed machine-learning. Alzheimers Dement. 2020 Mar;16(3):501-511. doi: 10.1002/alz.12032. Epub 2020 Feb 11. PubMed PMID: 32043733; PubMed Central PMCID: PMC7222030.
    94. Pichet Binette A, Vachon-Presseau É, Morris J, Bateman R, Benzinger T, Collins DL, Poirier J, Breitner JCS, Villeneuve S. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease. Biol Psychiatry. 2020 Feb 6;. doi: 10.1016/j.biopsych.2020.01.023. [Epub ahead of print] PubMed PMID: 32228870; PubMed Central PMCID: PMC7415608.
    95. Day GS, Rappai T, Sathyan S, Morris JC. Deciphering the factors that influence participation in studies requiring serial lumbar punctures. Alzheimers Dement (Amst). 2020;12(1):e12003. doi: 10.1002/dad2.12003. eCollection 2020. PubMed PMID: 32211499; PubMed Central PMCID: PMC7085282.
    96. Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, Farlow M, O’Connor A, Ghetti B, Graff-Radford N, Goldman J, Gräber S, Karch CM, Lee JH, Levin J, Martins RN, Masters C, Mori H, Noble J, Salloway S, Schofield P, Morris JC, Bateman RJ, Hassenstab J. Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimers Dement. 2020 Jan;16(1):219-228. doi: 10.1002/alz.12010. PubMed PMID: 31914221; PubMed Central PMCID: PMC7206736.
    97. Ng KP, Richard-Devantoy S, Bertrand JA, Jiang L, Pascoal TA, Mathotaarachchi S, Therriault J, Yatawara C, Kandiah N, Greenwood CMT, Rosa-Neto P, Gauthier S. Suicidal ideation is common in autosomal dominant Alzheimer’s disease at-risk persons. Int J Geriatr Psychiatry. 2020 Jan;35(1):60-68. doi: 10.1002/gps.5215. Epub 2019 Oct 22. PubMed PMID: 31642105; PubMed Central PMCID: PMC7232741.
    98. Lessov-Schlaggar CN, Del Rosario OL, Morris JC, Ances BM, Schlaggar BL, Constantino JN. Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome. J Neurodev Disord. 2019 Dec 16;11(1):39. doi: 10.1186/s11689-019-9300-2. PubMed PMID: 31842726; PubMed Central PMCID: PMC6912998.
    99. Llibre-Guerra JJ, Li Y, Schindler SE, Gordon BA, Fagan AM, Morris JC, Benzinger TLS, Hassenstab J, Wang G, Allegri R, Berman SB, Chhatwal J, Farlow MR, Holtzman DM, Jucker M, Levin J, Noble JM, Salloway S, Schofield P, Karch C, Fox NC, Xiong C, Bateman RJ, McDade E. Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease. JAMA Netw Open. 2019 Dec 2;2(12):e1917126. doi: 10.1001/jamanetworkopen.2019.17126. PubMed PMID: 31825500; PubMed Central PMCID: PMC6991202.
    100. Maserejian N, Bian S, Wang W, Jaeger J, Syrjanen JA, Aakre J, Jack CR Jr, Mielke MM, Gao F. Practical algorithms for amyloid β probability in subjective or mild cognitive impairment. Alzheimers Dement (Amst). 2019 Dec;11:180. doi: 10.1016/j.dadm.2019.09.001. eCollection 2019 Dec. PubMed PMID: 31700988; PubMed Central PMCID: PMC6827360.
    101. Su Y, Flores S, Wang G, Hornbeck RC, Speidel B, Joseph-Mathurin N, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Jack CR Jr, Farlow MR, Salloway S, Snider BJ, Berman SB, Roberson ED, Brosch J, Jimenez-Velazques I, van Dyck CH, Galasko D, Yuan SH, Jayadev S, Honig LS, Gauthier S, Hsiung GR, Masellis M, Brooks WS, Fulham M, Clarnette R, Masters CL, Wallon D, Hannequin D, Dubois B, Pariente J, Sanchez-Valle R, Mummery C, Ringman JM, Bottlaender M, Klein G, Milosavljevic-Ristic S, McDade E, Xiong C, Morris JC, Bateman RJ, Benzinger TLS. Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies. Alzheimers Dement (Amst). 2019 Dec;11:180-190. doi: 10.1016/j.dadm.2018.12.008. eCollection 2019 Dec. PubMed PMID: 30847382; PubMed Central PMCID: PMC6389727.
    102. Gallagher M, Okonkwo OC, Resnick SM, Jagust WJ, Benzinger TLS, Rapp PR. What are the threats to successful brain and cognitive aging?. Neurobiol Aging. 2019 Nov;83:130-134. doi: 10.1016/j.neurobiolaging.2019.04.016. PubMed PMID: 31732016; PubMed Central PMCID: PMC6859944.
    103. Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, Gentsch J, Wang F, Salloway S, Masters CL, Lee JH, Graff-Radford NR, Chhatwal JP, Bateman RJ, Morris JC, Karch CM, Harari O, Cruchaga C. An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nat Neurosci. 2019 Nov;22(11):1903-1912. doi: 10.1038/s41593-019-0501-5. Epub 2019 Oct 7. PubMed PMID: 31591557; PubMed Central PMCID: PMC6858549.
    104. Xiong C, Luo J, Agboola F, Li Y, Albert M, Johnson SC, Koscik RL, Masters CL, Soldan A, Villemagne VL, Li QX, McDade EM, Fagan AM, Massoumzadeh P, Benzinger T, Hassenstab J, Bateman RJ, Morris JC. A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer’s disease from young adulthood and for designing prevention trials. Alzheimers Dement. 2019 Nov;15(11):1448-1457. doi: 10.1016/j.jalz.2019.06.4955. Epub 2019 Sep 7. PubMed PMID: 31506247; PubMed Central PMCID: PMC6874758.
    105. Carpenter CR, McFarland F, Avidan M, Berger M, Inouye SK, Karlawish J, Lin FR, Marcantonio E, Morris JC, Reuben DB, Shah RC, Whitson HE, Asthana S, Verghese J. Impact of Cognitive Impairment Across Specialties: Summary of a Report From the U13 Conference Series. J Am Geriatr Soc. 2019 Oct;67(10):2011-2017. doi: 10.1111/jgs.16093. Epub 2019 Aug 22. PubMed PMID: 31436318; PubMed Central PMCID: PMC6800784.
    106. Schultz AP, Kloet RW, Sohrabi HR, van der Weerd L, van Rooden S, Wermer MJH, Moursel LG, Yaqub M, van Berckel BNM, Chatterjee P, Gardener SL, Taddei K, Fagan AM, Benzinger TL, Morris JC, Sperling R, Johnson K, Bateman RJ, Gurol ME, van Buchem MA, Martins R, Chhatwal JP, Greenberg SM. Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers. Ann Neurol. 2019 Oct;86(4):616-625. doi: 10.1002/ana.25560. Epub 2019 Aug 12. PubMed PMID: 31361916; PubMed Central PMCID: PMC6876775.
    107. Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk. Sci Transl Med. 2019 Aug 14;11(505). doi: 10.1126/scitranslmed.aau2291. PubMed PMID: 31413141; PubMed Central PMCID: PMC6697053.
    108. Navid J, Day GS, Strain J, Perrin RJ, Bucelli RC, Dincer A, Wisch JK, Soleimani-Meigooni D, Morris JC, Benzinger TLS, Ances BM. Structural signature of sporadic Creutzfeldt-Jakob disease. Eur J Neurol. 2019 Aug;26(8):1037-1043. doi: 10.1111/ene.13930. Epub 2019 Mar 25. PubMed PMID: 30735286; PubMed Central PMCID: PMC6615963.
    109. Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging. 2019 Jun;78:178-185. doi: 10.1016/j.neurobiolaging.2019.02.019. Epub 2019 Mar 7. PubMed PMID: 30947113; PubMed Central PMCID: PMC6545139.
    110. Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease. Brain. 2019 May 1;142(5):1429-1440. doi: 10.1093/brain/awz050. PubMed PMID: 30897203; PubMed Central PMCID: PMC6735903.
    111. Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2019 May;15(5):655-665. doi: 10.1016/j.jalz.2018.12.019. Epub 2019 Mar 4. PubMed PMID: 30846386; PubMed Central PMCID: PMC6511459.
    112. Gordon BA, Blazey TM, Christensen J, Dincer A, Flores S, Keefe S, Chen C, Su Y, McDade EM, Wang G, Li Y, Hassenstab J, Aschenbrenner A, Hornbeck R, Jack CR, Ances BM, Berman SB, Brosch JR, Galasko D, Gauthier S, Lah JJ, Masellis M, van Dyck CH, Mintun MA, Klein G, Ristic S, Cairns NJ, Marcus DS, Xiong C, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS. Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers. Brain. 2019 Apr 1;142(4):1063-1076. doi: 10.1093/brain/awz019. PubMed PMID: 30753379; PubMed Central PMCID: PMC6439328.
    113. Han JY, Besser LM, Xiong C, Kukull WA, Morris JC. Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia. Alzheimer Dis Assoc Disord. 2019 Apr-Jun;33(2):87-94. doi: 10.1097/WAD.0000000000000291. PubMed PMID: 30633043; PubMed Central PMCID: PMC6542289.
    114. Wang G, Coble D, McDade EM, Hassenstab J, Fagan AM, Benzinger TLS, Bateman RJ, Morris JC, Xiong C. Staging biomarkers in preclinical autosomal dominant Alzheimer’s disease by estimated years to symptom onset. Alzheimers Dement. 2019 Apr;15(4):506-514. doi: 10.1016/j.jalz.2018.12.008. Epub 2019 Feb 15. PubMed PMID: 30773445; PubMed Central PMCID: PMC6461496.
    115. Vöglein J, Noachtar S, McDade E, Quaid KA, Salloway S, Ghetti B, Noble J, Berman S, Chhatwal J, Mori H, Fox N, Allegri R, Masters CL, Buckles V, Ringman JM, Rossor M, Schofield PR, Sperling R, Jucker M, Laske C, Paumier K, Morris JC, Bateman RJ, Levin J, Danek A. Seizures as an early symptom of autosomal dominant Alzheimer’s disease. Neurobiol Aging. 2019 Apr;76:18-23. doi: 10.1016/j.neurobiolaging.2018.11.022. Epub 2018 Dec 5. PubMed PMID: 30616208; PubMed Central PMCID: PMC6572755.
    116. Wang Q, Wang Y, Liu J, Sutphen CL, Cruchaga C, Blazey T, Gordon BA, Su Y, Chen C, Shimony JS, Ances BM, Cairns NJ, Fagan AM, Morris JC, Benzinger TLS. Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer’s disease. Neuroimage Clin. 2019;22:101767. doi: 10.1016/j.nicl.2019.101767. Epub 2019 Mar 13. PubMed PMID: 30901713; PubMed Central PMCID: PMC6428957.
    117. Bussy A, Snider BJ, Coble D, Xiong C, Fagan AM, Cruchaga C, Benzinger TLS, Gordon BA, Hassenstab J, Bateman RJ, Morris JC. Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network. Neurobiol Aging. 2019 Mar;75:42-50. doi: 10.1016/j.neurobiolaging.2018.10.011. Epub 2018 Oct 13. PubMed PMID: 30530186; PubMed Central PMCID: PMC6385602.
    118. Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. Nat Med. 2019 Feb;25(2):277-283. doi: 10.1038/s41591-018-0304-3. Epub 2019 Jan 21. PubMed PMID: 30664784; PubMed Central PMCID: PMC6367005.
    119. Properzi MJ, Buckley RF, Chhatwal JP, Donohue MC, Lois C, Mormino EC, Johnson KA, Sperling RA, Schultz AP. Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. Neuroimage. 2019 Feb 1;186:446-454. doi: 10.1016/j.neuroimage.2018.11.019. Epub 2018 Nov 17. PubMed PMID: 30458305; PubMed Central PMCID: PMC6338495.
    120. Toedebusch CD, McLeland JS, Schaibley CM, Banks IR, Boyd J, Morris JC, Holtzman DM, Lucey BP. Multi-Modal Home Sleep Monitoring in Older Adults. J Vis Exp. 2019 Jan 26;(143). doi: 10.3791/58823. PubMed PMID: 30741255; PubMed Central PMCID: PMC6377867.
    121. Day GS, Gordon BA, Perrin RJ, Ances BM. Author response: In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease. Neurology. 2019 Jan 15;92(3):150. doi: 10.1212/WNL.0000000000006771. PubMed PMID: 30643031.
    123. Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease. Sci Transl Med. 2019 Jan 9;11(474). doi: 10.1126/scitranslmed.aau6550. PubMed PMID: 30626715; PubMed Central PMCID: PMC6342564.
    124. Roe CM, Stout SH, Rajasekar G, Ances BM, Jones JM, Head D, Benzinger TLS, Williams MM, Davis JD, Ott BR, Warren DK, Babulal GM. A 2.5-Year Longitudinal Assessment of Naturalistic Driving in Preclinical Alzheimer’s Disease. J Alzheimers Dis. 2019;68(4):1625-1633. doi: 10.3233/JAD-181242. PubMed PMID: 30958365; PubMed Central PMCID: PMC6488385.
    125. Barroeta-Espar I, Weinstock LD, Perez-Nievas BG, Meltzer AC, Siao Tick Chong M, Amaral AC, Murray ME, Moulder KL, Morris JC, Cairns NJ, Parisi JE, Lowe VJ, Petersen RC, Kofler J, Ikonomovic MD, López O, Klunk WE, Mayeux RP, Frosch MP, Wood LB, Gomez-Isla T. Distinct cytokine profiles in human brains resilient to Alzheimer’s pathology. Neurobiol Dis. 2019 Jan;121:327-337. doi: 10.1016/j.nbd.2018.10.009. Epub 2018 Oct 15. PubMed PMID: 30336198; PubMed Central PMCID: PMC6437670.
    126. Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ. Understanding disease progression and improving Alzheimer’s disease clinical trials: Recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement. 2019 Jan;15(1):106-152. doi: 10.1016/j.jalz.2018.08.005. Epub 2018 Oct 13. Review. PubMed PMID: 30321505.
    127. Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, Martinez R, Hsu S, Fernandez MV, Cairns NJ, Harari O, Cruchaga C, Karch CM. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Transl Psychiatry. 2018 Dec 13;8(1):265. doi: 10.1038/s41398-018-0319-z. PubMed PMID: 30546007; PubMed Central PMCID: PMC6293323.
    128. Wang G, Xiong C, McDade EM, Hassenstab J, Aschenbrenner AJ, Fagan AM, Benzinger TLS, Gordon BA, Morris JC, Li Y, Bateman RJ. Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer’s disease. Alzheimers Dement (N Y). 2018;4:669-676. doi: 10.1016/j.trci.2018.10.009. eCollection 2018. PubMed PMID: 30569014; PubMed Central PMCID: PMC6288312.
    129. Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Jucker M, Masters CL, Rossor MN, Ringman JM, Shaw LM, Trojanowski JQ, Weiner M, Ewers M, Haass C. CSF progranulin increases in the course of Alzheimer’s disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO Mol Med. 2018 Dec;10(12). doi: 10.15252/emmm.201809712. PubMed PMID: 30482868; PubMed Central PMCID: PMC6284390.
    130. Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, Nordberg A, White LR, Nielsen HM. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease. Acta Neuropathol Commun. 2018 Nov 26;6(1):130. doi: 10.1186/s40478-018-0624-z. PubMed PMID: 30477568; PubMed Central PMCID: PMC6260771.
    131. Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Fox NN, Graff-Radford NR, Levin J, Danek A, Vöglein J, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C. Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2018 Nov;14(11):1427-1437. doi: 10.1016/j.jalz.2018.06.3059. Epub 2018 Sep 25. PubMed PMID: 30266303; PubMed Central PMCID: PMC6322213.
    132. Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement. 2018 Nov;14(11):1460-1469. doi: 10.1016/j.jalz.2018.01.013. Epub 2018 Mar 2. PubMed PMID: 29501462; PubMed Central PMCID: PMC6119652.
    133. McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, Berman SB, Klunk W, Noble J, Ringman J, Ghetti B, Farlow M, Sperling RA, Chhatwal J, Salloway S, Graff-Radford NR, Schofield PR, Masters C, Rossor MN, Fox NC, Levin J, Jucker M, Bateman RJ. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. 2018 Oct 2;91(14):e1295-e1306. doi: 10.1212/WNL.0000000000006277. Epub 2018 Sep 14. PubMed PMID: 30217935; PubMed Central PMCID: PMC6177272.
    134. Besser L, Kukull W, Knopman DS, Chui H, Galasko D, Weintraub S, Jicha G, Carlsson C, Burns J, Quinn J, Sweet RA, Rascovsky K, Teylan M, Beekly D, Thomas G, Bollenbeck M, Monsell S, Mock C, Zhou XH, Thomas N, Robichaud E, Dean M, Hubbard J, Jacka M, Schwabe-Fry K, Wu J, Phelps C, Morris JC. Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set. Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):351-358. doi: 10.1097/WAD.0000000000000279. Review. PubMed PMID: 30376508; PubMed Central PMCID: PMC6249084.
    135. Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, Rossor M, Fox NC, Lee JH, Salloway S, Danek A, Goate A, Yakushev I, Hassenstab J, Schofield PR, Haass C, Ewers M. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease. Brain. 2018 Oct 1;141(10):3065-3080. doi: 10.1093/brain/awy229. PubMed PMID: 30239611; PubMed Central PMCID: PMC6158739.
    136. Day GS, Musiek ES, Morris JC. Rapidly Progressive Dementia in the Outpatient Clinic: More Than Prions. Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):291-297. doi: 10.1097/WAD.0000000000000276. PubMed PMID: 30222606; PubMed Central PMCID: PMC6249048.
    137. Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, Goate A, Jack CR Jr, Karch C, Klunk W, Koeppe RA, Marcus DS, Mayeux R, McDade E, Noble JM, Ringman J, Saykin AJ, Thompson PM, Xiong C, Morris JC, Bateman RJ, Benzinger TLS. Utility of perfusion PET measures to assess neuronal injury in Alzheimer’s disease. Alzheimers Dement (Amst). 2018;10:669-677. doi: 10.1016/j.dadm.2018.08.012. eCollection 2018. PubMed PMID: 30417072; PubMed Central PMCID: PMC6215983.
    138. Wang G, Berry S, Xiong C, Hassenstab J, Quintana M, McDade EM, Delmar P, Vestrucci M, Sethuraman G, Bateman RJ. A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer’s disease. Stat Med. 2018 Sep 20;37(21):3047-3055. doi: 10.1002/sim.7811. Epub 2018 May 14. PubMed PMID: 29761523; PubMed Central PMCID: PMC6105413.
    139. Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, Morris JC, Maruff P, Bateman RJ. Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer’s disease. Ann Neurol. 2018 Sep;84(3):424-435. doi: 10.1002/ana.25299. Epub 2018 Aug 25. PubMed PMID: 30014553; PubMed Central PMCID: PMC6153076.
    140. Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA. Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer’s disease: Findings from three well-characterized cohorts. Alzheimers Dement. 2018 Sep;14(9):1193-1203. doi: 10.1016/j.jalz.2018.04.010. Epub 2018 May 24. PubMed PMID: 29803541; PubMed Central PMCID: PMC6131023.
    141. Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, Morris JC, Bateman RJ, Pébay A, Goate AM. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimers Res Ther. 2018 Jul 25;10(1):69. doi: 10.1186/s13195-018-0400-0. PubMed PMID: 30045758; PubMed Central PMCID: PMC6060509.
    142. Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R Jr, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, Cruchaga C, Bateman RJ, Karch CM. Discovery and validation of autosomal dominant Alzheimer’s disease mutations. Alzheimers Res Ther. 2018 Jul 18;10(1):67. doi: 10.1186/s13195-018-0392-9. PubMed PMID: 30021643; PubMed Central PMCID: PMC6052673.
    143. Gabel M, Gooblar J, Roe CM, Selsor NJ, Morris JC. Political Ideology, Confidence in Science, and Participation in Alzheimer Disease Research Studies. Alzheimer Dis Assoc Disord. 2018 Jul-Sep;32(3):179-184. doi: 10.1097/WAD.0000000000000244. PubMed PMID: 29351092; PubMed Central PMCID: PMC6051930.
    144. Vlassenko AG, Gordon BA, Goyal MS, Su Y, Blazey TM, Durbin TJ, Couture LE, Christensen JJ, Jafri H, Morris JC, Raichle ME, Benzinger TL. Aerobic glycolysis and tau deposition in preclinical Alzheimer’s disease. Neurobiol Aging. 2018 Jul;67:95-98. doi: 10.1016/j.neurobiolaging.2018.03.014. Epub 2018 Mar 20. PubMed PMID: 29655050; PubMed Central PMCID: PMC5955846.
    145. Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ, Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O. Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure. Genome Med. 2018 Jun 8;10(1):43. doi: 10.1186/s13073-018-0551-4. PubMed PMID: 29880032; PubMed Central PMCID: PMC5992755.
    146. Carvalho DZ, St Louis EK, Knopman DS, Boeve BF, Lowe VJ, Roberts RO, Mielke MM, Przybelski SA, Machulda MM, Petersen RC, Jack CR Jr, Vemuri P. Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia. JAMA Neurol. 2018 Jun 1;75(6):672-680. doi: 10.1001/jamaneurol.2018.0049. PubMed PMID: 29532057; PubMed Central PMCID: PMC5885188.
    147. Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Fӧrster S, Schofield PR, Sperling RA, Johnson KA, Chhatwal JP, Salloway S, Correia S, Jack CR Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM. White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease. PLoS One. 2018;13(5):e0195838. doi: 10.1371/journal.pone.0195838. eCollection 2018. PubMed PMID: 29742105; PubMed Central PMCID: PMC5942789.
    148. Oxtoby NP, Young AL, Cash DM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Fox NC, Schott JM, Alexander DC. Data-driven models of dominantly-inherited Alzheimer’s disease progression. Brain. 2018 May 1;141(5):1529-1544. doi: 10.1093/brain/awy050. PubMed PMID: 29579160; PubMed Central PMCID: PMC5920320.
    149. Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA. Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain. 2018 May 1;141(5):1486-1500. doi: 10.1093/brain/awy053. PubMed PMID: 29522171; PubMed Central PMCID: PMC5917745.
    150. Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J. Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease. JAMA Neurol. 2018 May 1;75(5):608-619. doi: 10.1001/jamaneurol.2017.5135. PubMed PMID: 29482212; PubMed Central PMCID: PMC5885216.
    151. Petok JR, Myers CE, Pa J, Hobel Z, Wharton DM, Medina LD, Casado M, Coppola G, Gluck MA, Ringman JM. Impairment of memory generalization in preclinical autosomal dominant Alzheimer’s disease mutation carriers. Neurobiol Aging. 2018 May;65:149-157. doi: 10.1016/j.neurobiolaging.2018.01.022. Epub 2018 Feb 8. PubMed PMID: 29494861; PubMed Central PMCID: PMC5871602.
    152. Stout SH, Babulal GM, Ma C, Carr DB, Head DM, Grant EA, Williams MM, Holtzman DM, Fagan AM, Morris JC, Roe CM. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers. Alzheimers Dement. 2018 May;14(5):610-616. doi: 10.1016/j.jalz.2017.11.011. Epub 2018 Jan 10. PubMed PMID: 29328928; PubMed Central PMCID: PMC5938126.
    153. Su Y, Flores S, Hornbeck RC, Speidel B, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Xiong C, Morris JC, Benzinger TLS. Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies. Neuroimage Clin. 2018;19:406-416. doi: 10.1016/j.nicl.2018.04.022. eCollection 2018. PubMed PMID: 30035025; PubMed Central PMCID: PMC6051499.
    154. Allison S, Babulal GM, Stout SH, Barco PP, Carr DB, Fagan AM, Morris JC, Roe CM, Head D. Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults: Role of Spatial Navigation Abilities. Alzheimer Dis Assoc Disord. 2018 Apr-Jun;32(2):101-106. doi: 10.1097/WAD.0000000000000257. PubMed PMID: 29578861; PubMed Central PMCID: PMC5963990.
    155. Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease. Brain. 2018 Apr 1;141(4):1186-1200. doi: 10.1093/brain/awy008. PubMed PMID: 29462334; PubMed Central PMCID: PMC5888938.
    156. Day GS, Gordon BA, Perrin RJ, Cairns NJ, Beaumont H, Schwetye K, Ferguson C, Sinha N, Bucelli R, Musiek ES, Ghoshal N, Ponisio MR, Vincent B, Mishra S, Jackson K, Morris JC, Benzinger TLS, Ances BM. In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease. Neurology. 2018 Mar 6;90(10):e896-e906. doi: 10.1212/WNL.0000000000005064. Epub 2018 Feb 7. PubMed PMID: 29438042; PubMed Central PMCID: PMC5863493.
    157. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 Mar;21(3):424-431. doi: 10.1038/s41593-018-0070-z. Epub 2018 Feb 5. PubMed PMID: 29403032; PubMed Central PMCID: PMC5857215.
    158. Gordon BA, Blazey TM, Su Y, Hari-Raj A, Dincer A, Flores S, Christensen J, McDade E, Wang G, Xiong C, Cairns NJ, Hassenstab J, Marcus DS, Fagan AM, Jack CR Jr, Hornbeck RC, Paumier KL, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal JP, Correia S, Förster S, Fox NC, Graff-Radford NR, la Fougère C, Levin J, Masters CL, Rossor MN, Salloway S, Saykin AJ, Schofield PR, Thompson PM, Weiner MM, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS. Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer’s disease: a longitudinal study. Lancet Neurol. 2018 Mar;17(3):241-250. doi: 10.1016/S1474-4422(18)30028-0. Epub 2018 Feb 1. PubMed PMID: 29397305; PubMed Central PMCID: PMC5816717.
    159. Xiong C, Luo J, Chen L, Gao F, Liu J, Wang G, Bateman R, Morris JC. Estimating diagnostic accuracy for clustered ordinal diagnostic groups in the three-class case-Application to the early diagnosis of Alzheimer disease. Stat Methods Med Res. 2018 Mar;27(3):701-714. doi: 10.1177/0962280217742539. Epub 2017 Nov 28. PubMed PMID: 29182052; PubMed Central PMCID: PMC5841923.
    160. Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Deming Y, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, Harari O. Polygenic risk score of sporadic late-onset Alzheimer’s disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement. 2018 Feb;14(2):205-214. doi: 10.1016/j.jalz.2017.08.013. Epub 2017 Sep 21. PubMed PMID: 28943286; PubMed Central PMCID: PMC5803427.
    161. Owens TE, Machulda MM, Duffy JR, Strand EA, Clark HM, Boland S, Martin PR, Lowe VJ, Jack CR, Whitwell JL, Josephs KA. Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia. J Alzheimers Dis. 2018;66(3):1015-1025. doi: 10.3233/JAD-171175. PubMed PMID: 30372673; PubMed Central PMCID: PMC6322407.
    162. Luo J, Weng H, Morris JC, Xiong C. Minimizing the Sample Sizes of Clinical Trials on Preclinical and Early Symptomatic Stage of Alzheimer Disease. J Prev Alzheimers Dis. 2018;5(2):110-119. doi: 10.14283/jpad.2018.16. PubMed PMID: 29616704; PubMed Central PMCID: PMC6429951.
    163. Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O’Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL. Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. J Alzheimers Dis. 2018;62(3):965-992. doi: 10.3233/JAD-171145. Review. PubMed PMID: 29562546; PubMed Central PMCID: PMC5870031.
    164. Weintraub S, Besser L, Dodge HH, Teylan M, Ferris S, Goldstein FC, Giordani B, Kramer J, Loewenstein D, Marson D, Mungas D, Salmon D, Welsh-Bohmer K, Zhou XH, Shirk SD, Atri A, Kukull WA, Phelps C, Morris JC. Version 3 of the Alzheimer Disease Centers’ Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):10-17. doi: 10.1097/WAD.0000000000000223. PubMed PMID: 29240561; PubMed Central PMCID: PMC5821520.
    165. Yan L, Liu CY, Wong KP, Huang SC, Mack WJ, Jann K, Coppola G, Ringman JM, Wang DJJ. Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer’s disease. Neuroimage Clin. 2018;17:751-760. doi: 10.1016/j.nicl.2017.12.003. eCollection 2018. PubMed PMID: 29527482; PubMed Central PMCID: PMC5842754.
    166. Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway SP, Correia S, Sperling RA, Chhatwal JP, Mayeux RP, Brickman AM, Martins RN, Farlow MR, Ghetti B, Saykin AJ, Jack CR Jr, Schofield PR, McDade E, Weiner MW, Ringman JM, Thompson PM, Masters CL, Rowe CC, Rossor MN, Ourselin S, Fox NC. Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: A serial magnetic resonance imaging study. Alzheimers Dement. 2018 Jan;14(1):43-53. doi: 10.1016/j.jalz.2017.06.2268. Epub 2017 Jul 22. PubMed PMID: 28738187; PubMed Central PMCID: PMC5751893.
    167. Schindler SE, Sutphen CL, Teunissen C, McCue LM, Morris JC, Holtzman DM, Mulder SD, Scheltens P, Xiong C, Fagan AM. Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years. Alzheimers Dement. 2018 Jan;14(1):62-70. doi: 10.1016/j.jalz.2017.06.2264. Epub 2017 Jul 12. PubMed PMID: 28710906; PubMed Central PMCID: PMC5750131.
    168. Brown BM, Sohrabi HR, Taddei K, Gardener SL, Rainey-Smith SR, Peiffer JJ, Xiong C, Fagan AM, Benzinger T, Buckles V, Erickson KI, Clarnette R, Shah T, Masters CL, Weiner M, Cairns N, Rossor M, Graff-Radford NR, Salloway S, Vöglein J, Laske C, Noble J, Schofield PR, Bateman RJ, Morris JC, Martins RN. Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2017 Nov;13(11):1197-1206. doi: 10.1016/j.jalz.2017.03.008. Epub 2017 May 11. PubMed PMID: 28501451; PubMed Central PMCID: PMC5675772.
    169. Ringman JM, Casado M, Van Berlo V, Pa J, Joseph-Mathurin N, Fagan AM, Benzinger T, Bateman RJ, Morris JC. A novel PSEN1 (S230N) mutation causing early-onset Alzheimer’s Disease associated with prosopagnosia, hoarding, and Parkinsonism. Neurosci Lett. 2017 Sep 14;657:11-15. doi: 10.1016/j.neulet.2017.07.046. Epub 2017 Jul 29. PubMed PMID: 28764909; PubMed Central PMCID: PMC5731478.
    170. Gao F, Philip Miller J, Xiong C, Luo J, Beiser JA, Chen L, Gordon MO. Estimating correlation between multivariate longitudinal data in the presence of heterogeneity. BMC Med Res Methodol. 2017 Aug 17;17(1):124. doi: 10.1186/s12874-017-0398-1. PubMed PMID: 28818061; PubMed Central PMCID: PMC5561646.
    171. Goyal MS, Vlassenko AG, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME. Loss of Brain Aerobic Glycolysis in Normal Human Aging. Cell Metab. 2017 Aug 1;26(2):353-360.e3. doi: 10.1016/j.cmet.2017.07.010. PubMed PMID: 28768174; PubMed Central PMCID: PMC5573225.
    172. Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, Ikeda M, Kawakatsu S, Nakanishi A, Hashimoto M, Nunomura A, Matsubara E, Fukui M, Shirato T, Hirai K, Sakamoto M, Fujii H, Mori H. [DIAN/DIAN-J/DIAN-TU]. Brain Nerve. 2017 Jul;69(7):701-709. doi: 10.11477/mf.1416200811. PubMed PMID: 28739983.
    173. Weng H, Bateman R, Morris JC, Xiong C. Validity and power of minimization algorithm in longitudinal analysis of clinical trials. Biostat Epidemiol. 2017;1(1):59-77. doi: 10.1080/24709360.2017.1331822. Epub 2017 Jun 13. PubMed PMID: 29250611; PubMed Central PMCID: PMC5730087.
    174. Xiong C, Luo J, Morris JC, Bateman R. Linear Combinations of Multiple Outcome Measures to Improve the Power of Efficacy Analysis —Application to Clinical Trials on Early Stage Alzheimer Disease. Biostat Epidemiol. 2017;1(1):36-58. doi: 10.1080/24709360.2017.1331821. Epub 2017 Jun 2. PubMed PMID: 29546251; PubMed Central PMCID: PMC5849424.
    175. Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017 May 9;88(19):1814-1821. doi: 10.1212/WNL.0000000000003916. Epub 2017 Apr 12. PubMed PMID: 28404803; PubMed Central PMCID: PMC5419982.
    176. Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Dietzsch J, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Graff-Radford NR, Levin J, Galasko D, Quaid KA, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C. Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease. Sci Rep. 2017 Apr 27;7(1):1225. doi: 10.1038/s41598-017-01327-w. PubMed PMID: 28450713; PubMed Central PMCID: PMC5430642.
    177. Day GS, Gordon BA, Jackson K, Christensen JJ, Rosana Ponisio M, Su Y, Ances BM, Benzinger TLS, Morris JC. Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia. Alzheimer Dis Assoc Disord. 2017 Apr-Jun;31(2):87-93. doi: 10.1097/WAD.0000000000000196. PubMed PMID: 28394771; PubMed Central PMCID: PMC5443698.
    178. Su Y, Vlassenko AG, Couture LE, Benzinger TL, Snyder AZ, Derdeyn CP, Raichle ME. Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner. J Cereb Blood Flow Metab. 2017 Apr;37(4):1435-1446. doi: 10.1177/0271678X16656200. Epub 2016 Jan 1. PubMed PMID: 27401805; PubMed Central PMCID: PMC5453463.
    179. Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Gunter JL, Senjem ML, Jones DT, Kantarci K, Machulda MM, Mielke MM, Roberts RO, Vemuri P, Reyes DA, Petersen RC. Defining imaging biomarker cut points for brain aging and Alzheimer’s disease. Alzheimers Dement. 2017 Mar;13(3):205-216. doi: 10.1016/j.jalz.2016.08.005. Epub 2016 Sep 30. PubMed PMID: 27697430; PubMed Central PMCID: PMC5344738.
    180. Natelson Love M, Clark DG, Cochran JN, Den Beste KA, Geldmacher DS, Benzinger TL, Gordon BA, Morris JC, Bateman RJ, Roberson ED. Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer’s disease. Neurobiol Aging. 2017 Jan;49:216.e7-216.e13. doi: 10.1016/j.neurobiolaging.2016.09.020. Epub 2016 Oct 3. PubMed PMID: 27793474; PubMed Central PMCID: PMC5154842.
    181. Bateman RJ, Benzinger TL, Berry S, Clifford DB, Duggan C, Fagan AM, Fanning K, Farlow MR, Hassenstab J, McDade EM, Mills S, Paumier K, Quintana M, Salloway SP, Santacruz A, Schneider LS, Wang G, Xiong C. The DIAN-TU Next Generation Alzheimer’s prevention trial: Adaptive design and disease progression model. Alzheimers Dement. 2017 Jan;13(1):8-19. doi: 10.1016/j.jalz.2016.07.005. Epub 2016 Aug 29. PubMed PMID: 27583651; PubMed Central PMCID: PMC5218895.
    182. Gurney J, Olsen T, Flavin J, Ramaratnam M, Archie K, Ransford J, Herrick R, Wallace L, Cline J, Horton W, Marcus DS. The Washington University Central Neuroimaging Data Archive. Neuroimage. 2017 Jan;144(Pt B):287-293. doi: 10.1016/j.neuroimage.2015.09.060. Epub 2015 Oct 9. PubMed PMID: 26439514; PubMed Central PMCID: PMC4967044.
    183. Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C. Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury. Sci Transl Med. 2016 Dec 14;8(369):369ra178. doi: 10.1126/scitranslmed.aag1767. PubMed PMID: 27974666; PubMed Central PMCID: PMC5385711.
    184. Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ. Neurological manifestations of autosomal dominant familial Alzheimer’s disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). Lancet Neurol. 2016 Dec;15(13):1317-1325. doi: 10.1016/S1474-4422(16)30229-0. Epub 2016 Oct 21. Review. PubMed PMID: 27777020; PubMed Central PMCID: PMC5116769.
    185. Soosman SK, Joseph-Mathurin N, Braskie MN, Bordelon YM, Wharton D, Casado M, Coppola G, McCallum H, Nuwer M, Coutin-Churchman P, Apostolova LG, Benzinger T, Ringman JM. Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging. 2016 Nov;47:201-209. doi: 10.1016/j.neurobiolaging.2016.07.030. Epub 2016 Aug 8. PubMed PMID: 27614114; PubMed Central PMCID: PMC5075491.
    186. Chen L, Sun J, Xiong C. A multiple imputation approach to the analysis of clustered interval-censored failure time data with the additive hazards model. Comput Stat Data Anal. 2016 Nov;103:242-249. doi: 10.1016/j.csda.2016.05.011. Epub 2016 May 28. PubMed PMID: 27773956; PubMed Central PMCID: PMC5072417.
    187. Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TLS, Fagan AM, Morris JC, Roe CM. Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels. Am J Geriatr Psychiatry. 2016 Nov;24(11):1095-1104. doi: 10.1016/j.jagp.2016.04.004. Epub 2016 Apr 19. PubMed PMID: 27426238; PubMed Central PMCID: PMC5069099.
    188. Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, McDade E, Ringman JM, Rossor M, Salloway S, Schofield PR, Holtzman DM, Morris JC, Bateman RJ. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease. Brain. 2016 Oct;139(Pt 10):2766-2777. doi: 10.1093/brain/aww200. Epub 2016 Aug 12. PubMed PMID: 27521573; PubMed Central PMCID: PMC5815565.
    189. Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL. Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group. PLoS One. 2016;11(9):e0163669. doi: 10.1371/journal.pone.0163669. eCollection 2016. PubMed PMID: 27649320; PubMed Central PMCID: PMC5029931.
    190. Day GS, Musiek ES, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC. Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. JAMA Neurol. 2016 Sep 1;73(9):1125-32. doi: 10.1001/jamaneurol.2016.1236. PubMed PMID: 27454811; PubMed Central PMCID: PMC5025942.
    191. Muenchhoff J, Poljak A, Thalamuthu A, Gupta VB, Chatterjee P, Raftery M, Masters CL, Morris JC, Bateman RJ, Fagan AM, Martins RN, Sachdev PS. Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer’s disease. Sci Rep. 2016 Jul 6;6:29078. doi: 10.1038/srep29078. PubMed PMID: 27381087; PubMed Central PMCID: PMC4933916.
    192. Miller-Thomas MM, Sipe AL, Benzinger TL, McConathy J, Connolly S, Schwetye KE. Multimodality Review of Amyloid-related Diseases of the Central Nervous System. Radiographics. 2016 Jul-Aug;36(4):1147-63. doi: 10.1148/rg.2016150172. Review. PubMed PMID: 27399239; PubMed Central PMCID: PMC4976469.
    193. Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Ryan NS, Förster S, Laske C, Schofield PR, Sperling RA, Salloway S, Correia S, Jack C Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM. White matter hyperintensities are a core feature of Alzheimer’s disease: Evidence from the dominantly inherited Alzheimer network. Ann Neurol. 2016 Jun;79(6):929-39. doi: 10.1002/ana.24647. Epub 2016 Apr 27. PubMed PMID: 27016429; PubMed Central PMCID: PMC4884146.
    194. Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL. Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group. PLoS One. 2016;11(3):e0152082. doi: 10.1371/journal.pone.0152082. eCollection 2016. PubMed PMID: 27010959; PubMed Central PMCID: PMC4807073.
    195. Ringman JM, Monsell S, Ng DW, Zhou Y, Nguyen A, Coppola G, Van Berlo V, Mendez MF, Tung S, Weintraub S, Mesulam MM, Bigio EH, Gitelman DR, Fisher-Hubbard AO, Albin RL, Vinters HV. Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol. 2016 Mar;75(3):284-90. doi: 10.1093/jnen/nlv028. Epub 2016 Feb 17. PubMed PMID: 26888304; PubMed Central PMCID: PMC4934612.
    196. Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Compta Y, Revesz T, Lees A, Cairns NJ, Halliday GM, Mann D, Pickering-Brown S, Powell J, Lunnon K, Lupton MK, Dickson D, Hardy J, Singleton A, Bras J. Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson’s and Alzheimer’s diseases. Neurobiol Aging. 2016 Feb;38:214.e7-214.e10. doi: 10.1016/j.neurobiolaging.2015.10.028. Epub 2015 Nov 2. PubMed PMID: 26643944; PubMed Central PMCID: PMC4759606.
    197. Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN. Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study. J Alzheimers Dis. 2016;50(3):887-94. doi: 10.3233/JAD-150948. PubMed PMID: 26836186; PubMed Central PMCID: PMC4943576.
    198. Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S. CAP–advancing the evaluation of preclinical Alzheimer disease treatments. Nat Rev Neurol. 2016 Jan;12(1):56-61. doi: 10.1038/nrneurol.2015.177. Epub 2015 Sep 29. Review. PubMed PMID: 26416539; PubMed Central PMCID: PMC4847536.
    199. Luo J, D’Angela G, Gao F, Ding J, Xiong C. Bivariate correlation coefficients in family-type clustered studies. Biom J. 2015 Nov;57(6):1084-109. doi: 10.1002/bimj.201400131. Epub 2015 Sep 11. PubMed PMID: 26360805; PubMed Central PMCID: PMC4741284.
    200. Mielke MM, Machulda MM, Hagen CE, Edwards KK, Roberts RO, Pankratz VS, Knopman DS, Jack CR Jr, Petersen RC. Performance of the CogState computerized battery in the Mayo Clinic Study on Aging. Alzheimers Dement. 2015 Nov;11(11):1367-76. doi: 10.1016/j.jalz.2015.01.008. Epub 2015 Apr 6. PubMed PMID: 25858683; PubMed Central PMCID: PMC4595161.
    201. Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, Sperling R, Salloway S, Schofield PR, Masters CL, Martins RN, Rossor MN, Jucker M, Danek A, Förster S, Lane CA, Morris JC, Benzinger TL, Bateman RJ. Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology. 2015 Sep 1;85(9):790-8. doi: 10.1212/WNL.0000000000001903. Epub 2015 Aug 5. PubMed PMID: 26245925; PubMed Central PMCID: PMC4553024.
    202. Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, Bateman RJ. Age and amyloid effects on human central nervous system amyloid-beta kinetics. Ann Neurol. 2015 Sep;78(3):439-53. doi: 10.1002/ana.24454. Epub 2015 Jul 20. PubMed PMID: 26040676; PubMed Central PMCID: PMC4546566.
    203. Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramírez DL, Tariot PN, Dickerson BC, Sperling RA, Lopera F, Reiman EM. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol. 2015 Aug;72(8):912-9. doi: 10.1001/jamaneurol.2015.1099. PubMed PMID: 26121081; PubMed Central PMCID: PMC4625544.
    204. Yau WW, Tudorascu DL, McDade EM, Ikonomovic S, James JA, Minhas D, Mowrey W, Sheu LK, Snitz BE, Weissfeld L, Gianaros PJ, Aizenstein HJ, Price JC, Mathis CA, Lopez OL, Klunk WE. Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer’s disease: a prospective cohort study. Lancet Neurol. 2015 Aug;14(8):804-813. doi: 10.1016/S1474-4422(15)00135-0. Epub 2015 Jun 29. PubMed PMID: 26139022; PubMed Central PMCID: PMC4519011.
    205. Cairns NJ, Perrin RJ, Franklin EE, Carter D, Vincent B, Xie M, Bateman RJ, Benzinger T, Friedrichsen K, Brooks WS, Halliday GM, McLean C, Ghetti B, Morris JC. Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN). Neuropathology. 2015 Aug;35(4):390-400. doi: 10.1111/neup.12205. Epub 2015 May 12. PubMed PMID: 25964057; PubMed Central PMCID: PMC4521391.
    206. Grill JD, Bateman RJ, Buckles V, Oliver A, Morris JC, Masters CL, Klunk WE, Ringman JM. A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer’s disease. Alzheimers Res Ther. 2015;7(1):50. doi: 10.1186/s13195-015-0135-0. eCollection 2015. PubMed PMID: 26203303; PubMed Central PMCID: PMC4511231.
    207. Franklin EE, Perrin RJ, Vincent B, Baxter M, Morris JC, Cairns NJ. Brain collection, standardized neuropathologic assessment, and comorbidity in Alzheimer’s Disease Neuroimaging Initiative 2 participants. Alzheimers Dement. 2015 Jul;11(7):815-22. doi: 10.1016/j.jalz.2015.05.010. Review. PubMed PMID: 26194314; PubMed Central PMCID: PMC4511380.
    208. Bateman RJ, Morris JC. Factors Contributing to the Post-Lumbar Puncture Headache—Reply. JAMA Neurol. 2015 Jul;72(7):835. doi: 10.1001/jamaneurol.2015.0691. PubMed PMID: 26167902; PubMed Central PMCID: PMC4943573.
    209. Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM. Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer’s disease. Neuropsychologia. 2015 Jul;73:169-75. doi: 10.1016/j.neuropsychologia.2015.04.034. Epub 2015 May 19. PubMed PMID: 26002757; PubMed Central PMCID: PMC4479270.
    210. Schindler SE, Fagan AM. Autosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical AD. Front Neurol. 2015;6:142. doi: 10.3389/fneur.2015.00142. eCollection 2015. Review. PubMed PMID: 26175713; PubMed Central PMCID: PMC4483518.
    211. Su Y, Blazey TM, Snyder AZ, Raichle ME, Hornbeck RC, Aldea P, Morris JC, Benzinger TL. Quantitative amyloid imaging using image-derived arterial input function. PLoS One. 2015;10(4):e0122920. doi: 10.1371/journal.pone.0122920. eCollection 2015. PubMed PMID: 25849581; PubMed Central PMCID: PMC4388540.
    212. Laske C, Sohrabi HR, Jasielec MS, Müller S, Koehler NK, Gräber S, Förster S, Drzezga A, Mueller-Sarnowski F, Danek A, Jucker M, Bateman RJ, Buckles V, Saykin AJ, Martins RN, Morris JC, Dominantly Inherited Alzheimer Network Dian. Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. Biomed Res Int. 2015;2015:828120. doi: 10.1155/2015/828120. Epub 2015 Apr 2. PubMed PMID: 25922840; PubMed Central PMCID: PMC4398930.
    213. Ringman JM, Liang LJ, Zhou Y, Vangala S, Teng E, Kremen S, Wharton D, Goate A, Marcus DS, Farlow M, Ghetti B, McDade E, Masters CL, Mayeux RP, Rossor M, Salloway S, Schofield PR, Cummings JL, Buckles V, Bateman R, Morris JC. Early behavioural changes in familial Alzheimer’s disease in the Dominantly Inherited Alzheimer Network. Brain. 2015 Apr;138(Pt 4):1036-45. doi: 10.1093/brain/awv004. Epub 2015 Feb 15. PubMed PMID: 25688083; PubMed Central PMCID: PMC4963801.
    214. Monserrate AE, Ryman DC, Ma S, Xiong C, Noble JM, Ringman JM, Morris JC, Danek A, Müller-Sarnowski F, Clifford DB, McDade EM, Brooks WS, Darby DG, Masters CL, Weston PS, Farlow MR, Graff-Radford NR, Salloway SP, Fagan AM, Oliver A, Bateman RJ. Factors associated with the onset and persistence of post-lumbar puncture headache. JAMA Neurol. 2015 Mar;72(3):325-32. doi: 10.1001/jamaneurol.2014.3974. PubMed PMID: 25622095; PubMed Central PMCID: PMC4364538.
    215. Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gutierrez Gomez M, Langois CM, Langbaum JB, Roontiva A, Thiyyagura P, Lee W, Ayutyanont N, Lopez L, Moreno S, Muñoz C, Tirado V, Acosta-Baena N, Fagan AM, Giraldo M, Garcia G, Huentelman MJ, Tariot PN, Lopera F, Reiman EM. Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study. JAMA Neurol. 2015 Mar;72(3):316-24. doi: 10.1001/jamaneurol.2014.3314. PubMed PMID: 25580592; PubMed Central PMCID: PMC4355261.
    216. Su Y, Blazey TM, Snyder AZ, Raichle ME, Marcus DS, Ances BM, Bateman RJ, Cairns NJ, Aldea P, Cash L, Christensen JJ, Friedrichsen K, Hornbeck RC, Farrar AM, Owen CJ, Mayeux R, Brickman AM, Klunk W, Price JC, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Schofield PR, Buckles V, Morris JC, Benzinger TLS. Partial volume correction in quantitative amyloid imaging. Neuroimage. 2015 Feb 15;107:55-64. doi: 10.1016/j.neuroimage.2014.11.058. Epub 2014 Dec 5. PubMed PMID: 25485714; PubMed Central PMCID: PMC4300252.
    217. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb;72(2):209-16. doi: 10.1001/jamaneurol.2014.2157. PubMed PMID: 25531812; PubMed Central PMCID: PMC4324097.
    218. Chatterjee P, Gupta VB, Fagan AM, Jasielec MS, Xiong C, Sohrabi HR, Dhaliwal S, Taddei K, Bourgeat P, Brown BM, Benzinger T, Bateman RJ, Morris JC, Martins RN. Decreased platelet APP isoform ratios in autosomal dominant Alzheimer’s disease: baseline data from a DIAN cohort subset. Curr Alzheimer Res. 2015;12(2):157-64. doi: 10.2174/1567205012666150204125732. PubMed PMID: 25654503; PubMed Central PMCID: PMC4383703.
    219. Klunk WE, Koeppe RA, Price JC, Benzinger TL, Devous MD Sr, Jagust WJ, Johnson KA, Mathis CA, Minhas D, Pontecorvo MJ, Rowe CC, Skovronsky DM, Mintun MA. The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement. 2015 Jan;11(1):1-15.e1-4. doi: 10.1016/j.jalz.2014.07.003. Epub 2014 Oct 28. PubMed PMID: 25443857; PubMed Central PMCID: PMC4300247.
    220. Karch CM, Goate AM. Alzheimer’s disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry. 2015 Jan 1;77(1):43-51. doi: 10.1016/j.biopsych.2014.05.006. Epub 2014 May 17. Review. PubMed PMID: 24951455; PubMed Central PMCID: PMC4234692.
    221. Xiong C, Weng H, Bennett DA, Boyle PA, Shah RC, Fague S, Hall CB, Lipton RB, Morris JC. Subsets of a large cognitive battery better power clinical trials on early stage Alzheimer’s disease. Neuroepidemiology. 2014;43(2):131-9. doi: 10.1159/000365733. Epub 2014 Nov 5. PubMed PMID: 25376544; PubMed Central PMCID: PMC4237272.
    222. Raman MR, Wiste HJ, Senjem ML, Ward CP, Jack CR Jr, Kantarci K. Spontaneous amyloid-related imaging abnormalities in a cognitively normal adult. Neurology. 2014 Nov 4;83(19):1771-2. doi: 10.1212/WNL.0000000000000957. PubMed PMID: 25367059; PubMed Central PMCID: PMC4239833.
    223. Ringman JM, Goate A, Masters CL, Cairns NJ, Danek A, Graff-Radford N, Ghetti B, Morris JC. Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Curr Neurol Neurosci Rep. 2014 Nov;14(11):499. doi: 10.1007/s11910-014-0499-8. Review. PubMed PMID: 25217249; PubMed Central PMCID: PMC4162987.
    224. Brier MR, Thomas JB, Snyder AZ, Wang L, Fagan AM, Benzinger T, Morris JC, Ances BM. Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging. Neurology. 2014 Oct 28;83(18):1613-9. doi: 10.1212/WNL.0000000000000939. Epub 2014 Sep 26. PubMed PMID: 25261500; PubMed Central PMCID: PMC4223085.
    225. Pepe A, Dinov I, Tohka J. An automatic framework for quantitative validation of voxel based morphometry measures of anatomical brain asymmetry. Neuroimage. 2014 Oct 15;100:444-59. doi: 10.1016/j.neuroimage.2014.06.029. Epub 2014 Jun 18. PubMed PMID: 24952229; PubMed Central PMCID: PMC4457344.
    226. Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, Ourselin S, Schofield PR, Masters CL, Martins RN, Weiner MW, Thompson PM, Fox NC, Koeppe RA, Jack CR Jr, Mathis CA, Oliver A, Blazey TM, Moulder K, Buckles V, Hornbeck R, Chhatwal J, Schultz AP, Goate AM, Fagan AM, Cairns NJ, Marcus DS, Morris JC, Ances BM. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurol. 2014 Sep;71(9):1111-22. doi: 10.1001/jamaneurol.2014.1654. PubMed PMID: 25069482; PubMed Central PMCID: PMC4240274.
    227. Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, Moreno S, Reiman EM, Ringman JM, Salloway S, Schofield PR, Sperling R, Tariot PN, Xiong C, Morris JC, Bateman RJ. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014 Jul 15;83(3):253-60. doi: 10.1212/WNL.0000000000000596. Epub 2014 Jun 13. Review. PubMed PMID: 24928124; PubMed Central PMCID: PMC4117367.
    228. Yu P, Sun J, Wolz R, Stephenson D, Brewer J, Fox NC, Cole PE, Jack CR Jr, Hill DL, Schwarz AJ. Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging. 2014 Apr;35(4):808-18. doi: 10.1016/j.neurobiolaging.2013.09.039. Epub 2013 Oct 3. PubMed PMID: 24211008; PubMed Central PMCID: PMC4201941.
    229. Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer’s disease. Sci Transl Med. 2014 Mar 5;6(226):226ra30. doi: 10.1126/scitranslmed.3007901. PubMed PMID: 24598588; PubMed Central PMCID: PMC4038930.
    230. Dong T, Kang L, Hutson A, Xiong C, Tian L. Confidence interval estimation of the difference between two sensitivities to the early disease stage. Biom J. 2014 Mar;56(2):270-86. doi: 10.1002/bimj.201200012. Epub 2013 Nov 22. PubMed PMID: 24265123; PubMed Central PMCID: PMC4349212.
    231. Grill JD, Monsell SE. Choosing Alzheimer’s disease prevention clinical trial populations. Neurobiol Aging. 2014 Mar;35(3):466-71. doi: 10.1016/j.neurobiolaging.2013.09.001. Epub 2013 Oct 9. PubMed PMID: 24119546; PubMed Central PMCID: PMC3864603.
    232. Armstrong RA, Kotzbauer PT, Perlmutter JS, Campbell MC, Hurth KM, Schmidt RE, Cairns NJ. A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease. J Neural Transm (Vienna). 2014 Feb;121(2):171-81. doi: 10.1007/s00702-013-1084-z. Epub 2013 Aug 31. PubMed PMID: 23996276; PubMed Central PMCID: PMC4041534.
    233. Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, Hsu S, Choi J, Ryten M, Sassi C, Bras J, Gibbs RJ, Hernandez DG, Lupton MK, Powell J, Forabosco P, Ridge PG, Corcoran CD, Tschanz JT, Norton MC, Munger RG, Schmutz C, Leary M, Demirci FY, Bamne MN, Wang X, Lopez OL, Ganguli M, Medway C, Turton J, Lord J, Braae A, Barber I, Brown K, Pastor P, Lorenzo-Betancor O, Brkanac Z, Scott E, Topol E, Morgan K, Rogaeva E, Singleton A, Hardy J, Kamboh MI, George-Hyslop PS, Cairns N, Morris JC, Kauwe JSK, Goate AM. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease. Nature. 2014 Jan 23;505(7484):550-554. doi: 10.1038/nature12825. Epub 2013 Dec 11. PubMed PMID: 24336208; PubMed Central PMCID: PMC4050701.
    234. Gordon BA, Blazey T, Benzinger TL. Regional variability in Alzheimer’s disease biomarkers. Future Neurol. 2014;9(2):131-134. doi: 10.2217/fnl.14.9. PubMed PMID: 25309132; PubMed Central PMCID: PMC4192718.
    235. Ting SK, Benzinger T, Kepe V, Fagan A, Coppola G, Porter V, Hecimovic S, Chakraverty S, Alvarez-Retuerto AI, Goate A, Ringman JM. A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer’s disease in an African-American woman. J Alzheimers Dis. 2014;40(2):271-5. doi: 10.3233/JAD-131844. PubMed PMID: 24413619; PubMed Central PMCID: PMC3972314.
    236. Xiong C, Luo J, Gao F, Morris JC. Optimizing parameters in clinical trials with a randomized start or withdrawal design. Comput Stat Data Anal. 2014 Jan 1;69:101-113. doi: 10.1016/j.csda.2013.07.013. PubMed PMID: 24159249; PubMed Central PMCID: PMC3804275.
    237. Storandt M, Balota DA, Aschenbrenner AJ, Morris JC. Clinical and psychological characteristics of the initial cohort of the Dominantly Inherited Alzheimer Network (DIAN). Neuropsychology. 2014 Jan;28(1):19-29. doi: 10.1037/neu0000030. Epub 2013 Nov 11. PubMed PMID: 24219606; PubMed Central PMCID: PMC3877741.
    238. Kang L, Xiong C, Tian L. Estimating confidence intervals for the difference in diagnostic accuracy with three ordinal diagnostic categories without a gold standard. Comput Stat Data Anal. 2013 Dec;68. doi: 10.1016/j.csda.2013.07.007. PubMed PMID: 24415817; PubMed Central PMCID: PMC3883051.
    239. Royle NA, Booth T, Valdés Hernández MC, Penke L, Murray C, Gow AJ, Maniega SM, Starr J, Bastin ME, Deary IJ, Wardlaw JM. Estimated maximal and current brain volume predict cognitive ability in old age. Neurobiol Aging. 2013 Dec;34(12):2726-33. doi: 10.1016/j.neurobiolaging.2013.05.015. Epub 2013 Jul 11. PubMed PMID: 23850342; PubMed Central PMCID: PMC3988920.
    240. Benzinger TL, Blazey T, Jack CR Jr, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, Christensen JJ, Ercole L, Hornbeck RC, Farrar AM, Aldea P, Jasielec MS, Owen CJ, Xie X, Mayeux R, Brickman A, McDade E, Klunk W, Mathis CA, Ringman J, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Salloway S, Correia S, Schofield PR, Masters CL, Rowe C, Villemagne VL, Martins R, Ourselin S, Rossor MN, Fox NC, Cash DM, Weiner MW, Holtzman DM, Buckles VD, Moulder K, Morris JC. Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4502-9. doi: 10.1073/pnas.1317918110. Epub 2013 Nov 5. PubMed PMID: 24194552; PubMed Central PMCID: PMC3839740.
    241. Su Y, D’Angelo GM, Vlassenko AG, Zhou G, Snyder AZ, Marcus DS, Blazey TM, Christensen JJ, Vora S, Morris JC, Mintun MA, Benzinger TL. Quantitative analysis of PiB-PET with FreeSurfer ROIs. PLoS One. 2013;8(11):e73377. doi: 10.1371/journal.pone.0073377. eCollection 2013. PubMed PMID: 24223109; PubMed Central PMCID: PMC3819320.
    242. Peters KR, Lynn Beattie B, Feldman HH, Illes J. A conceptual framework and ethics analysis for prevention trials of Alzheimer Disease. Prog Neurobiol. 2013 Nov;110:114-23. doi: 10.1016/j.pneurobio.2012.12.001. Epub 2013 Jan 21. Review. PubMed PMID: 23348495.
    243. Moulder KL, Snider BJ, Mills SL, Buckles VD, Santacruz AM, Bateman RJ, Morris JC. Dominantly Inherited Alzheimer Network: facilitating research and clinical trials. Alzheimers Res Ther. 2013;5(5):48. doi: 10.1186/alzrt213. eCollection 2013. Review. PubMed PMID: 24131566; PubMed Central PMCID: PMC3978584.
    244. Cash DM, Ridgway GR, Liang Y, Ryan NS, Kinnunen KM, Yeatman T, Malone IB, Benzinger TL, Jack CR Jr, Thompson PM, Ghetti BF, Saykin AJ, Masters CL, Ringman JM, Salloway SP, Schofield PR, Sperling RA, Cairns NJ, Marcus DS, Xiong C, Bateman RJ, Morris JC, Rossor MN, Ourselin S, Fox NC. The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study. Neurology. 2013 Oct 15;81(16):1425-33. doi: 10.1212/WNL.0b013e3182a841c6. Epub 2013 Sep 18. PubMed PMID: 24049139; PubMed Central PMCID: PMC3806583.
    245. Shimada H. [The DIAN study]. Brain Nerve. 2013 Oct;65(10):1179-84. Review. PubMed PMID: 24101429.
    246. Wang L, Brier MR, Snyder AZ, Thomas JB, Fagan AM, Xiong C, Benzinger TL, Holtzman DM, Morris JC, Ances BM. Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity. JAMA Neurol. 2013 Oct;70(10):1242-8. doi: 10.1001/jamaneurol.2013.3253. PubMed PMID: 23959173; PubMed Central PMCID: PMC3836828.
    247. Frost SM, Kanagasingam Y, Sohrabi HR, Taddei K, Bateman R, Morris J, Benzinger T, Goate A, Masters CL, Martins RN. Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers. Curr Alzheimer Res. 2013 Oct;10(8):790-6. doi: 10.2174/15672050113109990154. PubMed PMID: 23919771; PubMed Central PMCID: PMC3879087.
    248. Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, Farlow M, Fox N, Ghetti B, Goate AM, Heinrichs D, Hornbeck R, Jack C, Jucker M, Klunk WE, Marcus DS, Martins RN, Masters CM, Mayeux R, McDade E, Morris JC, Oliver A, Ringman JM, Rossor MN, Salloway S, Schofield PR, Snider J, Snyder P, Sperling RA, Stewart C, Thomas RG, Xiong C, Bateman RJ. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris). 2013 Oct;169(10):737-43. doi: 10.1016/j.neurol.2013.07.017. Epub 2013 Sep 6. Review. PubMed PMID: 24016464; PubMed Central PMCID: PMC3880800.
    249. Duchek JM, Balota DA, Thomas JB, Snyder AZ, Rich P, Benzinger TL, Fagan AM, Holtzman DM, Morris JC, Ances BM. Relationship between Stroop performance and resting state functional connectivity in cognitively normal older adults. Neuropsychology. 2013 Sep;27(5):516-28. doi: 10.1037/a0033402. PubMed PMID: 24040929; PubMed Central PMCID: PMC3837537.
    250. Hooper M, Grill JD, Rodriguez-Agudelo Y, Medina LD, Fox M, Alvarez-Retuerto AI, Wharton D, Brook J, Ringman JM. The impact of the availability of prevention studies on the desire to undergo predictive testing in persons at risk for autosomal dominant Alzheimer’s disease. Contemp Clin Trials. 2013 Sep;36(1):256-62. doi: 10.1016/j.cct.2013.07.006. Epub 2013 Jul 19. PubMed PMID: 23876673; PubMed Central PMCID: PMC3858206.
    251. Chhatwal JP, Schultz AP, Johnson K, Benzinger TL, Jack C Jr, Ances BM, Sullivan CA, Salloway SP, Ringman JM, Koeppe RA, Marcus DS, Thompson P, Saykin AJ, Correia S, Schofield PR, Rowe CC, Fox NC, Brickman AM, Mayeux R, McDade E, Bateman R, Fagan AM, Goate AM, Xiong C, Buckles VD, Morris JC, Sperling RA. Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology. 2013 Aug 20;81(8):736-44. doi: 10.1212/WNL.0b013e3182a1aafe. Epub 2013 Jul 24. PubMed PMID: 23884042; PubMed Central PMCID: PMC3776464.
    252. Liu CY, Krishnan AP, Yan L, Smith RX, Kilroy E, Alger JR, Ringman JM, Wang DJ. Complexity and synchronicity of resting state blood oxygenation level-dependent (BOLD) functional MRI in normal aging and cognitive decline. J Magn Reson Imaging. 2013 Jul;38(1):36-45. doi: 10.1002/jmri.23961. Epub 2012 Dec 7. PubMed PMID: 23225622; PubMed Central PMCID: PMC3610850.
    253. Xiong C, van Belle G, Chen K, Tian L, Luo J, Gao F, Yan Y, Chen L, Morris JC, Crane P. Combining Multiple Markers to Improve the Longitudinal Rate of Progression-Application to Clinical Trials on the Early Stage of Alzheimer’s Disease. Stat Biopharm Res. 2013 Jan 1;5(1). doi: 10.1080/19466315.2012.756662. PubMed PMID: 24363827; PubMed Central PMCID: PMC3868484.
    254. Luo J, Xiong C. Youden index and Associated Cut-points for Three Ordinal Diagnostic Groups. Commun Stat Simul Comput. 2013 Jan;42(6):1213-1234. doi: 10.1080/03610918.2012.661906. PubMed PMID: 23794784; PubMed Central PMCID: PMC3685301.
    255. Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clin Investig (Lond). 2012 Oct 1;2(10):975-984. doi: 10.4155/cli.12.93. PubMed PMID: 23139856; PubMed Central PMCID: PMC3489185.
    256. Luo J, Xiong C. DiagTest3Grp: An R Package for Analyzing Diagnostic Tests with Three Ordinal Groups. J Stat Softw. 2012 Oct;51(3):1-24. doi: 10.18637/jss.v051.i03. Epub 2012 Sep 22. PubMed PMID: 23504300; PubMed Central PMCID: PMC3595562.
    257. Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med. 2012 Aug 30;367(9):795-804. doi: 10.1056/NEJMoa1202753. Epub 2012 Jul 11. PubMed PMID: 22784036; PubMed Central PMCID: PMC3474597.
    258. Ryan NS, Bastos-Leite AJ, Rohrer JD, Werring DJ, Fox NC, Rossor MN, Schott JM. Cerebral microbleeds in familial Alzheimer’s disease. Brain. 2012 Jan;135(Pt 1):e201; author reply e202. doi: 10.1093/brain/awr126. Epub 2011 Jun 17. PubMed PMID: 21685457; PubMed Central PMCID: PMC3859452.
    259. Ryan NS, Rossor MN. Defining and describing the pre-dementia stages of familial Alzheimer’s disease. Alzheimers Res Ther. 2011 Sep 27;3(5):29. doi: 10.1186/alzrt91. PubMed PMID: 21952009; PubMed Central PMCID: PMC3218806.
    260. Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Gilbert PE, Liang LJ, Cummings JL, Ringman JM. Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer’s disease. Dement Geriatr Cogn Disord. 2011;32(3):188-92. doi: 10.1159/000333023. Epub 2011 Aug 30. PubMed PMID: 22134129; PubMed Central PMCID: PMC3542946.
    261. Holtzman DM, Morris JC, Goate AM. Alzheimer’s disease: the challenge of the second century. Sci Transl Med. 2011 Apr 6;3(77):77sr1. doi: 10.1126/scitranslmed.3002369. Review. PubMed PMID: 21471435; PubMed Central PMCID: PMC3130546.
    262. Xiong C, van Belle G, Miller JP, Morris JC. Designing clinical trials to test disease-modifying agents: application to the treatment trials of Alzheimer’s disease. Clin Trials. 2011 Feb;8(1):15-26. doi: 10.1177/1740774510392391. PubMed PMID: 21335587; PubMed Central PMCID: PMC3146242.
    263. Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimers Res Ther. 2011 Jan 6;3(1):1. doi: 10.1186/alzrt59. PubMed PMID: 21211070; PubMed Central PMCID: PMC3109410.
    264. Ryan NS, Rossor MN. Correlating familial Alzheimer’s disease gene mutations with clinical phenotype. Biomark Med. 2010 Feb;4(1):99-112. doi: 10.2217/bmm.09.92. Review. PubMed PMID: 20387306; PubMed Central PMCID: PMC3937872.
    265. Ringman JM, Grill J, Rodriguez-Agudelo Y, Chavez M, Xiong C. Commentary on “a roadmap for the prevention of dementia II: Leon Thal Symposium 2008.” Prevention trials in persons at risk for dominantly inherited Alzheimer’s disease: opportunities and challenges. Alzheimers Dement. 2009 Mar;5(2):166-71. doi: 10.1016/j.jalz.2008.12.002. Review. PubMed PMID: 19328453; PubMed Central PMCID: PMC2746429.